公开(公告)号：US20100178350A1

公开(公告)日：2010-07-15

申请号：US12697563

申请日：2010-02-01

申请人： Mitsuyasu IDA ,  Nobutaka Ninomiya

发明人： Mitsuyasu IDA ,  Nobutaka Ninomiya

IPC分类号： A61K9/14 ,  A61K31/197 ,  A61P43/00 ,  A23L1/305

CPC分类号： A61K31/198 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1682 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/0654

摘要： The present invention aims to provide an amino acid-containing granule preparation improved in the ease of taking medication than conventional products, which disintegrates rapidly. The amino acid-containing granule preparation of the present invention containing granules having a maximum particle size of substantially not more than 1000 μm and a bulk density of not less than 0.57 g/mL markedly improves ease of taking medication without impairing disintegration property, as compared to conventional amino acid-containing granule preparations.

摘要翻译： 本发明的目的在于提供一种比常规产品易于服用的含氨基酸的颗粒剂，其快速崩解。 含有最大粒径基本不大于1000μm，堆积密度不小于0.57g / mL的颗粒的本发明的含氨基酸颗粒剂显着提高了服用药物的便利性，而不损害其崩解性能 与常规含氨基酸的颗粒制剂。

公开(公告)号：US20050003015A1

公开(公告)日：2005-01-06

申请号：US10897000

申请日：2004-07-23

申请人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

发明人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

IPC分类号： A61J3/06 ,  A61K9/00 ,  A61K9/16 ,  A61K31/198 ,  A61K47/04 ,  A61K47/12 ,  A61P1/16 ,  A61K9/14

CPC分类号： A61K9/0095 ,  A61K9/1617 ,  A61K9/1635 ,  A61K31/198

摘要： The problem of the present invention is to provide pharmaceutical granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine, which has a smaller specific volume than conventional products, and a production method thereof. As a result of intensive studies, granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine and a production method thereof have been provided, which are characterized by adding an acid to a particle mixture of three kinds of branched chain amino acids of isoleucine, leucine and valine and granulating the mixture, which has solved the above-mentioned problem.

摘要翻译： 本发明的问题是提供含有作为活性氨基酸成分的异氰酸，亮氨酸，缬氨酸三种支链氨基酸的药物颗粒，其具有比常规产品更小的比容量及其制备方法。 作为深入研究的结果，提供了含有作为活性氨基酸成分的异亮氨酸，亮氨酸和缬氨酸的三种支链氨基酸的颗粒及其制备方法，其特征在于将酸添加到 3种异亮氨酸，亮氨酸，缬氨酸的支链氨基酸，混合造粒，解决了上述问题。

公开(公告)号：US09301937B2

公开(公告)日：2016-04-05

申请号：US12697563

申请日：2010-02-01

申请人： Mitsuyasu Ida ,  Nobutaka Ninomiya

发明人： Mitsuyasu Ida ,  Nobutaka Ninomiya

IPC分类号： A61K9/14 ,  A23L1/30 ,  A61K31/198 ,  A23L1/305 ,  A61K9/16

CPC分类号： A61K31/198 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1682 ,  A23V2250/0626 ,  A23V2250/0628 ,  A23V2250/0654

摘要： The present invention aims to provide an amino acid-containing granule preparation improved in the ease of taking medication than conventional products, which disintegrates rapidly. The amino acid-containing granule preparation of the present invention containing granules having a maximum particle size of substantially not more than 1000 μm and a bulk density of not less than 0.57 g/mL markedly improves ease of taking medication without impairing disintegration property, as compared to conventional amino acid-containing granule preparations.

公开(公告)号：US07138142B2

公开(公告)日：2006-11-21

申请号：US10897000

申请日：2004-07-23

申请人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

发明人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

IPC分类号： A61K9/14 ,  A61K9/50

CPC分类号： A61K9/0095 ,  A61K9/1617 ,  A61K9/1635 ,  A61K31/198

摘要： The problem of the present invention is to provide pharmaceutical granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine, which has a smaller specific volume than conventional products, and a production method thereof. As a result of intensive studies, granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine and a production method thereof have been provided, which are characterized by adding an acid to a particle mixture of three kinds of branched chain amino acids of isoleucine, leucine and valine and granulating the mixture, which has solved the above-mentioned problem.

摘要翻译： 本发明的问题是提供含有作为活性氨基酸成分的异氰酸，亮氨酸，缬氨酸三种支链氨基酸的药物颗粒，其具有比常规产品更小的比容量及其制备方法。 作为深入研究的结果，提供了含有作为活性氨基酸成分的异亮氨酸，亮氨酸和缬氨酸的三种支链氨基酸的颗粒及其制备方法，其特征在于将酸添加到 3种异亮氨酸，亮氨酸，缬氨酸的支链氨基酸，混合造粒，解决了上述问题。