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1.发明申请METHODS OF PREPARING SAMPLES FOR MALDI MASS SPECTROMETRY AND REAGENT COMPOSITIONS FOR THE SAME 失效制备用于MALDI质谱的样品和其试剂组合物的方法公开(公告)号：US20080067343A1
公开(公告)日：2008-03-20
申请号：US11772799
申请日：2007-07-02
IPC分类号： B01D59/44
CPC分类号： G01N33/6851 , H01J49/0418
摘要： A simple and efficient method of preparing a sample in the measurement according to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) capable of inhibiting any ion suppression by impurities, such as inorganic salts and surfactants, contained in the sample. An analyte and matrix molecules are co-crystallized in the presence of porous microparticles. Preferably, this co-crystallization is carried out by bringing the analyte, matrix molecules and porous microparticles into contact with each other on a target plate and thereafter drying the mixture. The porous microparticles consist of an ion exchanger having an average particle diameter of not more than 50 μm, preferably a strongly basic anion exchanger.
摘要翻译： 根据能够抑制样品中所含杂质如无机盐和表面活性剂的任何离子抑制的基质辅助激光解吸/电离质谱法（MALDI-MS），在测量中制备样品的简单有效的方法。 分析物和基质分子在多孔微粒存在下共结晶。 优选地，通过使分析物，基质分子和多孔微粒在靶板上彼此接触，然后干燥混合物来进行共结晶。 多孔微粒由平均粒径不大于50μm，优选强碱性阴离子交换剂的离子交换剂组成。
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2.发明授权Methods of preparing samples for MALDI mass spectrometry and reagent compositions for the same 失效制备MALDI质谱法样品的方法及其试剂组合物公开(公告)号：US07928367B2
公开(公告)日：2011-04-19
申请号：US11772799
申请日：2007-07-02
IPC分类号： B01D59/44
CPC分类号： G01N33/6851 , H01J49/0418
摘要： A simple and efficient method of preparing a sample in the measurement according to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) capable of inhibiting any ion suppression by impurities, such as inorganic salts and surfactants, contained in the sample. An analyte and matrix molecules are co-crystallized in the presence of porous microparticles. Preferably, this co-crystallization is carried out by bringing the analyte, matrix molecules and porous microparticles into contact with each other on a target plate and thereafter drying the mixture. The porous microparticles consist of an ion exchanger having an average particle diameter of not more than 50 μm, preferably a strongly basic anion exchanger.
摘要翻译： 根据能够抑制样品中所含杂质如无机盐和表面活性剂的任何离子抑制的基质辅助激光解吸/电离质谱法（MALDI-MS），在测量中制备样品的简单有效的方法。 分析物和基质分子在多孔微粒存在下共结晶。 优选地，通过使分析物，基质分子和多孔微粒在靶板上彼此接触，然后干燥混合物来进行共结晶。 多孔微粒由平均粒径不大于50μm的离子交换剂组成，优选强碱性阴离子交换剂。
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