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公开(公告)号：US20140378435A1
公开(公告)日：2014-12-25
申请号：US14479952
申请日：2014-09-08
IPC分类号： A61K31/554 , A61K31/145 , A61K31/435 , A61K31/4745
CPC分类号： A61K31/554 , A61K31/18 , A61K31/277 , A61K31/366 , A61K31/435 , A61K31/4741 , A61K31/4745 , A61K31/5377 , A61K31/713 , A61K33/00
摘要： The present invention discloses method to treat infections caused by filovirus. Such a method comprises blocking the PI3 kinase pathway or the calcium-associated pathway at the gene or protein level. Also disclosed herein are the compounds useful in the treatment of filoviral infection.
摘要翻译： 本发明公开了治疗由病毒感染引起的感染的方法。 这种方法包括在基因或蛋白质水平上阻断PI3激酶途径或钙相关途径。 本文还公开了可用于治疗火山病毒感染的化合物。
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公开(公告)号：US08889743B2
公开(公告)日：2014-11-18
申请号：US12653916
申请日：2009-12-21
IPC分类号： A61K31/135 , A61K31/18 , A61K31/277 , A61K31/713 , A61K31/4741 , A61K31/366 , A61K31/554 , A61K33/00 , A61K31/435 , A61K31/5377
CPC分类号： A61K31/554 , A61K31/18 , A61K31/277 , A61K31/366 , A61K31/435 , A61K31/4741 , A61K31/4745 , A61K31/5377 , A61K31/713 , A61K33/00
摘要： The present invention discloses method to treat infections caused by filovirus. Such a method comprises blocking the PI3 kinase pathway or the calcium-associated pathway at the gene or protein level. Also disclosed herein are the compounds useful in the treatment of filoviral infection.
摘要翻译： 本发明公开了治疗由病毒感染引起的感染的方法。 这种方法包括在基因或蛋白质水平上阻断PI3激酶途径或钙相关途径。 本文还公开了可用于治疗火山病毒感染的化合物。
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公开(公告)号：US20110152344A1
公开(公告)日：2011-06-23
申请号：US12653916
申请日：2009-12-21
IPC分类号： A61K31/7088 , C12N5/02 , A61K31/137 , C12Q1/70
CPC分类号： A61K31/554 , A61K31/18 , A61K31/277 , A61K31/366 , A61K31/435 , A61K31/4741 , A61K31/4745 , A61K31/5377 , A61K31/713 , A61K33/00
摘要： The present invention discloses method to treat infections caused by filovirus. Such a method comprises blocking the PI3 kinase pathway or the calcium-associated pathway at the gene or protein level. Also disclosed herein are the compounds useful in the treatment of filoviral infection.
摘要翻译： 本发明公开了治疗由病毒感染引起的感染的方法。 这种方法包括在基因或蛋白质水平上阻断PI3激酶途径或钙相关途径。 本文还公开了可用于治疗火山病毒感染的化合物。
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公开(公告)号：US06320027B1
公开(公告)日：2001-11-20
申请号：US09463005
申请日：2000-01-14
IPC分类号： C07K14175
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/12022
摘要： The present invention provides DNA encoding an Oropouche NP protein selected from the group consisting of: (a) isolated DNA which encodes an Oropouche NP protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes an Oropouche NP protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes an Oropouche NP protein. Also provided is a kit for the immunodetection of Oropouche virus.
摘要翻译： 本发明提供了编码选自下组的Oropouche NP蛋白的DNA：（a）编码Oropouche NP蛋白的分离的DNA; （b）与上述（a）的分离的DNA杂交并编码Oropouche NP蛋白的分离的DNA; 和（c）由于遗传密码的简并性而编码Oropouche NP蛋白的密码子序列中与（a）和（b）分离的DNA不同的分离的DNA。 还提供了用于免疫检测Oropouche病毒的试剂盒。
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