公开(公告)号：US20100004187A1

公开(公告)日：2010-01-07

申请号：US12494750

申请日：2009-06-30

申请人： Eddie L. Chang ,  Daniel Zabetakis ,  Andy Knight ,  Monique L. van Hoek

发明人： Eddie L. Chang ,  Daniel Zabetakis ,  Andy Knight ,  Monique L. van Hoek

IPC分类号： A61K31/295 ,  A61K31/65 ,  A61K31/7048 ,  A61P31/04

CPC分类号： A61K31/295 ,  A61K31/65 ,  A61K31/7048 ,  Y02A50/473

摘要： Disclosed herein is a method of: administering to a subject suspected of being infected with a bacterium, a composition of a cobalt (III) compound having the formula CoR1R2R3R4R5R6 or a salt thereof and an antibiotic compound. Each of R1, R2, R3, R4, and R5 is the same or different and includes an N-based ligand donor atom selected from the group consisting of ammonia, primary amine, or secondary amine, or salt thereof. R6 is a ligand. Also disclosed herein is a composition of the above cobalt (III) compound and an antibiotic compound. Also disclosed herein is a method of administering the above cobalt (III) compound to a subject diagnosed as needing a broad spectrum antibiotic

摘要翻译： 本文公开了一种方法：向疑似感染细菌的受试者施用具有式CoR 1 R 3 R 4 R 5 R 6的钴（III）化合物或其盐和抗生素化合物的组合物。 R 1，R 2，R 3，R 4和R 5各自相同或不同，并且包括选自氨，伯胺或仲胺或其盐的基于N的配体供体原子。 R6是配体。 本文还公开了上述钴（III）化合物和抗生素化合物的组合物。 本文还公开了将上述钴（III）化合物施用于被诊断为需要广谱抗生素的受试者的方法