公开(公告)号：US20110152379A1

公开(公告)日：2011-06-23

申请号：US12737553

申请日：2009-07-24

申请人： Sang Chul Park ,  Junho Lee ,  Sung Chun Cho ,  Moon Cheol Park ,  Yun Je Cho

发明人： Sang Chul Park ,  Junho Lee ,  Sung Chun Cho ,  Moon Cheol Park ,  Yun Je Cho

IPC分类号： A61K31/145 ,  A61K8/46 ,  A61P31/04 ,  A61P17/00 ,  A61Q19/08

CPC分类号： A61K31/63 ,  Y02A50/411

摘要： The present invention relates to a composition for controlling aging and/or extending lifespan. More specifically, the present invention relates to a composition containing dapsone as an effective component for controlling aging and/or extending lifespan, in which when applying the composition according to the present invention to an object, the effect of controlling aging or extending lifespan is excellent. Specifically, the treatment of dapsone (DDS) increases the lifespan of C. elegans not depending upon daf-16 and delays aging process, and reduces the activity of cytoplasmic dual oxidase 1 (Duox1) and mitochondria complex V protein. In addition, dapsone can maintain the low oxygen uptake rate in C. elegans thereby reducing ROS formation. In addition, ROS production by paraquat that is an inducing material of oxidative stress is reduced by treating dapsone and the sensitivity of paraquat is reduced. Moreover, it can be known that pyruvate kinase is a target material of dapsone through the structural prediction, molecular and biochemical analysis. In addition, there is an effect that the recovery of mitochondria function that is reduced and the decrease of NOX expression in a cell are obtained by dapsone in the human diploid fibroblast. From the comprehensive results, it can be known that dapsone has an excellent effect for extending lifespan in a cell level and object level.

摘要翻译： 本发明涉及一种用于控制老化和/或延长寿命的组合物。 更具体地，本发明涉及含有氨苯砜作为控制老化和/或延长寿命的有效成分的组合物，其中当将根据本发明的组合物施用于物体时，控制老化或延长寿命的效果是优异的 。 具体来说，氨苯砜（DDS）的治疗增加了不依赖于daf-16的线虫的寿命，延缓衰老过程，降低细胞质双氧化酶1（Duox1）和线粒体复合物V蛋白的活性。 此外，氨苯砜可维持秀丽隐杆线虫的低氧摄取率，从而降低ROS的形成。 另外，通过治疗氨苯砜来减少百草枯作为氧化应激诱导物质的ROS产生，百草枯的敏感性降低。 此外，可以知道丙酮酸激酶是通过结构预测，分子和生物化学分析的氨苯砜的靶材料。 另外，通过人二倍体成纤维细胞中的氨苯砜可以获得降低的线粒体功能的恢复和细胞中NOX表达的降低的作用。 从综合结果可以看出，氨苯砜具有延长细胞水平和对象水平的寿命的极好效果。