公开(公告)号：US20060241707A9

公开(公告)日：2006-10-26

申请号：US10754887

申请日：2004-01-10

申请人： Morton Mower

发明人： Morton Mower

IPC分类号： A61N1/365

CPC分类号： A61N1/3622 ,  A61B2017/00044 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0095 ,  A61F2007/126 ,  A61N1/3624

摘要： Systems and methods to inhibit the conduction of certain spurious electrical impulses in the heart. Inhibition of spurious electrical impulses in the heart is accomplished by cooling one or more targeted portions of the heart. Optionally, inhibition of spurious electrical impulses may be accomplished by cooling of cardiac tissue in combination with pacing of the heart.

摘要翻译： 抑制心脏中某些杂散电脉冲传导的系统和方法。 通过冷却心脏的一个或多个目标部分来实现对心脏中的杂散电脉冲的抑制。 任选地，可以通过与心脏的起搏相结合来冷却心脏组织来实现寄生电脉冲的抑制。

公开(公告)号：US20060265017A9

公开(公告)日：2006-11-23

申请号：US11141403

申请日：2005-05-31

申请人： Morton Mower

发明人： Morton Mower

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provide to both healthy and compromised cardiac tissue.

摘要翻译： 一种用于管理和抑制MI患者心脏重塑的系统和方法。 不间断地提供双心室刺激，有助于不受感染，以鼓励心脏正常泵送。 使用阳极脉冲随后阴极脉冲施用脉冲以刺激心肌收缩。 将干细胞施用于MI区域以促进损伤区域中心脏组织的再生。 刺激可以提供健康和妥协的心脏组织。

公开(公告)号：US20060217774A1

公开(公告)日：2006-09-28

申请号：US11442519

申请日：2006-05-26

申请人： Morton Mower ,  Jon Roberts ,  Elliott Light

发明人： Morton Mower ,  Jon Roberts ,  Elliott Light

IPC分类号： A61N1/362

CPC分类号： A61N1/3627

摘要： A cardiac contractile augmentation device (CCAD) comprising an EAP segment adapted to be attached to a portion of the heart that would benefit from contractile augmentation. The EAP segment is energized by a pulse generator. In response to an electrical pulse the EAP segment deforms resulting in a contraction of the portion of the heart to which the EAP fabric is attached. In response to another pulse from the pulse generator, the EAP segments returns to its pre-deformed state. A CCAD may be constructed of EAP segments that are independently energized under control of a processor that is connected to the individual segments. The processor causes the pulse generator to sequentially pulse the individual segments in the direction of a normal contraction of the cardiac tissue. In this way, the CCAP provides contractile augmentation to a chamber of the heart in a pattern that is equivalent to a concentric contraction of normal heart muscle. Sensors may be used to provide the processor data indicative of the state of the heart and the need for contractile augmentation. The CCAD may be configured as a cardiac patch, a cardiac wrap, or a cardiac envelope. The EAP segments may be energized during systole to augment the contractile strength of the heart. The EAP segments may also be energized during diastole to provide a passive restraint precisely calibrated to the degree of restraint desired. Moreover, the active cardiac envelope may be energized during both systole and diastole. Networks of EAP sensors and contractile device may be use to provide the sensing and contractile functionality. Alternatively, a dual function EAP may perform both sensing and contractile functions.

摘要翻译： 一种心脏收缩增强装置（CCAD），其包括适于附接到将从收缩增大中受益的一部分心脏的EAP段。 EAP段由脉冲发生器供电。 响应于电脉冲，EAP区段变形，导致EAP结构附着到心脏部分的收缩。 响应来自脉冲发生器的另一个脉冲，EAP段返回到其预变形状态。 CCAD可以由EAP段构成，其在连接到各个段的处理器的控制下独立地通电。 处理器使得脉冲发生器在心脏组织的正常收缩的方向上顺序地脉冲各个区段。 以这种方式，CCAP以相当于正常心肌的同心收缩的图案向心脏室提供收缩增大。 可以使用传感器来提供指示心脏状态的处理器数据和收缩增加的需要。 CCAD可以被配置为心脏贴片，心脏包裹物或心脏包膜。 在收缩期间，EAP节段可以被激发以增加心脏的收缩强度。 舒张期期间，EAP节段也可以被激活，以提供被精确校准到所需约束程度的被动约束。 此外，活动心包可以在收缩期和舒张期期间通电。 EAP传感器和收缩装置的网络可用于提供感测和收缩功能。 或者，双功能EAP可以执行感测和收缩功能。

公开(公告)号：US20050021096A1

公开(公告)日：2005-01-27

申请号：US10625526

申请日：2003-07-24

申请人： Morton Mower

发明人： Morton Mower

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： Methods, apparatus, and systems are provided to stimulate multiple sites in a heart. A controller senses electrical activity associated with sinus rhythm of the heart. A signal generator is configured to generate an electrical signal for stimulating the heart. Based on the electrical signal, a distributor circuit then distributes the stimulating signals, such as pacing pulses, to a heart. The distributor circuit may vary the delay time between stimulating signals, inhibit a stimulating signal, trigger application of a stimulating signal, or vary the characteristics, such as the pulse width and amplitude, of a stimulating signal.

摘要翻译： 提供方法，装置和系统以刺激心脏中的多个部位。 控制器感测与心脏窦性心律相关的电活动。 信号发生器被配置为产生用于刺激心脏的电信号。 基于电信号，分配器电路然后将刺激信号（例如起搏脉冲）分配到心脏。 分配器电路可以改变刺激信号之间的延迟时间，抑制刺激信号，触发施加刺激信号，或改变刺激信号的特性，例如脉冲宽度和幅度。

公开(公告)号：US20070208387A1

公开(公告)日：2007-09-06

申请号：US11745593

申请日：2007-05-08

申请人： Morton MOWER

发明人： Morton MOWER

IPC分类号： A61N1/36

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： Methods, apparatus, and systems are provided to stimulate multiple sites in a heart. A controller senses electrical activity associated with sinus rhythm of the heart. A signal generator is configured to generate an electrical signal for stimulating the heart. Based on the electrical signal, a distributor circuit then distributes the stimulating signals, such as pacing pulses, to a heart. The distributor circuit may vary the delay time between stimulating signals, inhibit a stimulating signal, trigger application of a stimulating signal, or vary the characteristics, such as the pulse width and amplitude, of a stimulating signal.

摘要翻译： 提供方法，装置和系统以刺激心脏中的多个部位。 控制器感测与心脏窦性心律相关的电活动。 信号发生器被配置为产生用于刺激心脏的电信号。 基于电信号，分配器电路然后将刺激信号（例如起搏脉冲）分配到心脏。 分配器电路可以改变刺激信号之间的延迟时间，抑制刺激信号，触发施加刺激信号，或改变刺激信号的特性，例如脉冲宽度和幅度。

公开(公告)号：US20050277993A1

公开(公告)日：2005-12-15

申请号：US11141403

申请日：2005-05-31

申请人： Morton Mower

发明人： Morton Mower

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provide to both healthy and compromised cardiac tissue.

摘要翻译： 一种用于管理和抑制MI患者心脏重塑的系统和方法。 不间断地提供双心室刺激，有助于不受感染，以鼓励心脏正常泵送。 使用阳极脉冲随后阴极脉冲施用脉冲以刺激心肌收缩。 将干细胞施用于MI区域以促进损伤区域中心脏组织的再生。 刺激可以提供健康和妥协的心脏组织。

公开(公告)号：US20070191893A1

公开(公告)日：2007-08-16

申请号：US11692114

申请日：2007-03-27

申请人： Morton MOWER

发明人： Morton MOWER

IPC分类号： A61N1/362

CPC分类号： A61N1/368 ,  A61N1/3627

摘要： Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. The electrical activity is monitored and analyzed to detect an event. In addition, the electrical activity is monitored to detect, for example, premature stimulation and contraction of a portion of the heart, such as the left ventricle. Contraction in the pre-excited portion of the heart is then suppressed using electrical pulses. The heart may then be allowed to contract naturally, or a stimulating pulse may be applied to assist the heart in contracting.

摘要翻译： 提供了方法，装置和系统来控制心脏收缩。 至少一个感测元件接收指示心脏的窦性心律的电活动的信号。 监测和分析电活动以检测事件。 此外，监测电活动以检测例如心脏的一部分例如左心室的过早刺激和收缩。 然后使用电脉冲抑制心脏的预激动部分的收缩。 然后可以让心脏自然收缩，或者可以施加刺激性脉搏来帮助心脏收缩。

公开(公告)号：US20050055058A1

公开(公告)日：2005-03-10

申请号：US10656222

申请日：2003-09-08

申请人： Morton Mower

发明人： Morton Mower

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/36592 ,  A61N1/3627 ,  A61N1/3684

摘要： Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. Based on the received signals, the progress of contraction of the heart is determined. Based on the progress of contraction, the chamber of the heart may then be stimulated at a plurality of locations. In another embodiment, a plurality of electrodes are implanted in the left ventricle to stimulate at multiple locations in the left ventricle for the purpose of improving hemodynamic performance and increasing cardiac output in a patient who is suffering from congestive heart failure. A pre-excitation voltage may be applied to pre-condition a portion of the heart. A stimulation pulse of increased current may also be applied to improve cardiac output.

摘要翻译： 提供了方法，装置和系统来控制心脏收缩。 至少一个感测元件接收指示心脏的窦性心律的电活动的信号。 根据收到的信号，确定心脏收缩的进展。 基于收缩的进展，可以在多个位置刺激心脏室。 在另一个实施例中，为了改善患有充血性心力衰竭的患者的血液动力学性能和增加心输出量，在左心室中植入多个电极以在左心室的多个位置处进行刺激。 可以施加预激电压以预处理心脏的一部分。 也可以施加增加电流的刺激脉冲以改善心输出量。

公开(公告)号：US20050055057A1

公开(公告)日：2005-03-10

申请号：US10654959

申请日：2003-09-05

申请人： Morton Mower

发明人： Morton Mower

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/368 ,  A61N1/3627

摘要： Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. The electrical activity is monitored and analyzed to detect an event. In addition, the electrical activity is monitored to detect, for example, premature stimulation and contraction of a portion of the heart, such as the left ventricle. Contraction in the pre-excited portion of the heart is then suppressed using, for example, one or more anodal electrical pulses. The heart may then be allowed to contract naturally, or a stimulating pulse may be applied to assist the heart in contracting.

摘要翻译： 提供了方法，装置和系统来控制心脏收缩。 至少一个感测元件接收指示心脏的窦性心律的电活动的信号。 监测和分析电活动以检测事件。 此外，监测电活动以检测例如心脏的一部分例如左心室的过早刺激和收缩。 然后使用例如一个或多个阳极电脉冲来抑制心脏的预激动部分的收缩。 然后可以让心脏自然收缩，或者可以施加刺激性脉搏来帮助心脏收缩。