公开(公告)号：US20080033166A1

公开(公告)日：2008-02-07

申请号：US11628248

申请日：2005-06-03

申请人： Yoichi Nishioka ,  Msahiro Ito ,  Yutaka Kameyama

发明人： Yoichi Nishioka ,  Msahiro Ito ,  Yutaka Kameyama

IPC分类号： C07D501/04

CPC分类号： C07D501/00

摘要： A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (2) or an alkali metal salt thereof, the process being characterized in that an aqueous solution of an alkali metal salt of 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) is treated with a high porous polymer and/or active carbon as added thereto.

摘要翻译： 制备式（1）的7-氨基-3 - [（E / Z）-2-（4-甲基噻唑-5-基）乙烯基] -3-头孢烯-4-羧酸和碱金属盐 所述酸和所述盐的结构改善了式（7）的7-氨基-3 - [（Z）-2-（4-甲基噻唑-5-基）乙烯基] -3-头孢烯-4-羧酸的含量 2）或其碱金属盐，该方法的特征在于将7-氨基-3 - [（E / Z）-2-（4-甲基噻唑-5-基）乙烯基] 式（1）的3-头孢烯-4-羧酸用加入其中的高多孔聚合物和/或活性炭进行处理。