公开(公告)号：US4521417A

公开(公告)日：1985-06-04

申请号：US501391

申请日：1983-06-06

申请人： Hiromasa Nakamoto ,  Michitaka Ogawa ,  Muneo Kobayashi ,  Yuki Nogami ,  Kazuo Kumamoto ,  Hiroko Murakami ,  Yoichi Ninagawa ,  Yoshiaki Omura ,  Masao Mizuno

发明人： Hiromasa Nakamoto ,  Michitaka Ogawa ,  Muneo Kobayashi ,  Yuki Nogami ,  Kazuo Kumamoto ,  Hiroko Murakami ,  Yoichi Ninagawa ,  Yoshiaki Omura ,  Masao Mizuno

IPC分类号： C07D295/18 ,  A61K31/495 ,  A61P1/04 ,  C07D295/185 ,  C07D241/04

CPC分类号： C07D295/185

摘要： A geranylgeranylacetamide compound having a piperazine ring represented by the following formula (I) ##STR1## wherein R represents a member selected from the class consisting of a hydrogen atom, C.sub.1 -C.sub.5 alkyl groups which are unsubstituted or mono-substituted by a halogen atom, C.sub.2 -C.sub.5 alkenyl groups and C.sub.7 -C.sub.8 aralkyl groups, R.sub.1 represents a C.sub.1 -C.sub.3 alkyl group, and n represents 0, 1 or 2,and a pharmaceutically acceptable acid addition salt thereof. The aforesaid compound can be prepared by reacting geranylgeranylacetic acid or its reactive derivative with a piperazine compound, and thereafter, if desired, transforming the free geranylgeranylacetamide compound thus obtained into its pharmaceutically acceptable acid addition salt. A pharmaceutical composition containing said compound exhibits antiulcerogenic activity, particularly excellent antipeptic ulcerogenic activity, and is useful as an agent for treating ulcers.

摘要翻译： 具有下式（I）表示的哌嗪环的香叶基香叶基乙酰胺化合物其中R表示选自氢原子，未被取代或未被单取代的C 1 -C 5烷基的成员 卤素原子，C 2 -C 5烯基和C 7 -C 8芳烷基，R 1表示C 1 -C 3烷基，n表示0,1或2，以及其药学上可接受的酸加成盐。 上述化合物可以通过将香叶基香叶基香叶基乙酸或其活性衍生物与哌嗪化合物反应制备，然后如果需要，将由此获得的游离er牛儿基ger牛儿基乙酰胺化合物转化为其药学上可接受的酸加成盐。 含有所述化合物的药物组合物具有抗溃疡活性，特别优异的消毒性溃疡发生活性，可用作治疗溃疡的药剂。