公开(公告)号：US20090121727A1

公开(公告)日：2009-05-14

申请号：US12209318

申请日：2008-09-12

申请人： JEROME P. LYNCH ,  Tsung-Chin Huo ,  Nicholas A. Kotov ,  Nadine Wong Shi Kam ,  Kenneth J. Loh

发明人： JEROME P. LYNCH ,  Tsung-Chin Huo ,  Nicholas A. Kotov ,  Nadine Wong Shi Kam ,  Kenneth J. Loh

IPC分类号： G01N27/02

CPC分类号： G01R27/02

摘要： The present teachings relate to the application of electrical impedance tomography (EIT) to demonstrate the multifunctionality of carbon nanocomposite thin films under various types of environmental stimuli. Carbon nanotube (CNT) thin films are fabricated by a layer-by-layer (LbL) technique or other techniques and mounted with electrodes along their boundaries. The response of the thin films to various stimuli determined by relying on electric current excitation and corresponding boundary potential measurements. The spatial conductivity variations are reconstructed based on a mathematical model for the EIT technique. Here, the ability of the EIT method to provide two-dimensional mapping of the conductivity of CNT thin films is validated by (1) electrically imaging intentional structural defects in the thin films and (2) mapping the film's response to various pH environments.

摘要翻译： 本教导涉及电阻抗层析成像（EIT）的应用，以证明在各种环境刺激下碳纳米复合薄膜的多功能性。 碳纳米管（CNT）薄膜通过逐层（LbL）技术或其他技术制造，并沿其边界安装电极。 通过依靠电流激励和对应的边界电位测量确定薄膜对各种刺激的响应。 基于EIT技术的数学模型重建空间电导率变化。 在这里，EIT方法提供CNT薄膜电导率的二维映射的能力通过（1）电沉积薄膜中有意的结构缺陷和（2）将薄膜的响应映射到各种pH环境来验证。

公开(公告)号：US08159235B2

公开(公告)日：2012-04-17

申请号：US12209318

申请日：2008-09-12

申请人： Jerome P. Lynch ,  Tsung-Chin Huo ,  Nicholas A. Kotov ,  Nadine Wong Shi Kam ,  Kenneth J. Loh

发明人： Jerome P. Lynch ,  Tsung-Chin Huo ,  Nicholas A. Kotov ,  Nadine Wong Shi Kam ,  Kenneth J. Loh

IPC分类号： G01R27/08

CPC分类号： G01R27/02

摘要： The present teachings relate to the application of electrical impedance tomography (EIT) to demonstrate the multifunctionality of carbon nanocomposite thin films under various types of environmental stimuli. Carbon nanotube (CNT) thin films are fabricated by a layer-by-layer (LbL) technique or other techniques and mounted with electrodes along their boundaries. The response of the thin films to various stimuli determined by relying on electric current excitation and corresponding boundary potential measurements. The spatial conductivity variations are reconstructed based on a mathematical model for the EIT technique. Here, the ability of the EIT method to provide two-dimensional mapping of the conductivity of CNT thin films is validated by (1) electrically imaging intentional structural defects in the thin films and (2) mapping the film's response to various pH environments.

摘要翻译： 本教导涉及电阻抗层析成像（EIT）的应用，以证明在各种环境刺激下碳纳米复合薄膜的多功能性。 碳纳米管（CNT）薄膜通过逐层（LbL）技术或其他技术制造，并沿其边界安装电极。 通过依靠电流激励和对应的边界电位测量确定薄膜对各种刺激的响应。 基于EIT技术的数学模型重建空间电导率变化。 在这里，EIT方法提供CNT薄膜电导率的二维映射的能力通过（1）电沉积薄膜中有意的结构缺陷和（2）将薄膜的响应映射到各种pH环境来验证。

公开(公告)号：US20130034610A1

公开(公告)日：2013-02-07

申请号：US13566740

申请日：2012-08-03

申请人： Hongjie DAI ,  Nadine Wong Shi KAM ,  Paul A. WENDER ,  Zhuang LIU

发明人： Hongjie DAI ,  Nadine Wong Shi KAM ,  Paul A. WENDER ,  Zhuang LIU

IPC分类号： A61K9/14 ,  A61K38/02 ,  A61K38/43 ,  A61K48/00 ,  A61P35/00 ,  A61K31/7088 ,  A61K39/44 ,  B82Y5/00 ,  B82Y40/00

CPC分类号： C12N15/87 ,  A61K47/6925 ,  B82Y5/00

摘要： Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes and wires, functionalized with a linking group that is covalently bound to the nanotubes, or, alternatively, to the biologically active molecule, such as a protein. The biologically active molecule is preferably released from the nanotube when the complex has been taken up in an endosome.

摘要翻译： 提供了将生物活性分子体外或体内递送至细胞的方法和材料。 方法和材料使用碳纳米管或其它疏水性颗粒，管和线，其与共价结合到纳米管的连接基团官能化，或者可选地与生物活性分子如蛋白质官能化。 当复合物已经在内体中被吸收时，生物活性分子优选从纳米管释放出来。

公开(公告)号：US08795734B2

公开(公告)日：2014-08-05

申请号：US13566740

申请日：2012-08-03

申请人： Hongjie Dai ,  Nadine Wong Shi Kam ,  Paul A. Wender ,  Zhuang Liu

发明人： Hongjie Dai ,  Nadine Wong Shi Kam ,  Paul A. Wender ,  Zhuang Liu

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/54 ,  A61K39/00 ,  B82Y5/00 ,  C12N15/11 ,  A61K48/00

CPC分类号： C12N15/87 ,  A61K47/6925 ,  B82Y5/00

摘要： Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes and wires, functionalized with a linking group that is covalently bound to the nanotubes, or, alternatively, to the biologically active molecule, such as a protein. The biologically active molecule is preferably released from the nanotube when the complex has been taken up in an endosome.

摘要翻译： 提供了将生物活性分子体外或体内递送至细胞的方法和材料。 方法和材料使用碳纳米管或其它疏水性颗粒，管和线，其与共价结合到纳米管的连接基团官能化，或者可选地与生物活性分子如蛋白质官能化。 当复合物已经在内体中被吸收时，生物活性分子优选从纳米管释放出来。

公开(公告)号：US08246995B2

公开(公告)日：2012-08-21

申请号：US11431346

申请日：2006-05-09

申请人： Hongjie Dai ,  Nadine Wong Shi Kam ,  Paul A. Wender ,  Zhuang Liu

发明人： Hongjie Dai ,  Nadine Wong Shi Kam ,  Paul A. Wender ,  Zhuang Liu

IPC分类号： A61K9/14 ,  A61K9/16 ,  A01N61/00 ,  D01F9/12

CPC分类号： C12N15/87 ,  A61K47/6925 ,  B82Y5/00

摘要： Methods and materials for delivering biologically active molecules to cells in vitro or in vivo are provided. The methods and materials use carbon nanotubes or other hydrophobic particles, tubes and wires, functionalized with a linking group that is covalently bound to the nanotubes, or, alternatively, to the biologically active molecule, such as a protein. The biologically active molecule is preferably released from the nanotube when the complex has been taken up in an endosome.

摘要翻译： 提供了将生物活性分子体外或体内递送至细胞的方法和材料。 方法和材料使用碳纳米管或其它疏水性颗粒，管和线，其与共价结合到纳米管的连接基团官能化，或者可选地与生物活性分子如蛋白质官能化。 当复合物已经在内体中被吸收时，生物活性分子优选从纳米管释放出来。