公开(公告)号：US07199100B2

公开(公告)日：2007-04-03

申请号：US10381734

申请日：2001-10-02

申请人： Natacha Betz ,  Andreas Bikfalvi ,  Gerard Deleris

发明人： Natacha Betz ,  Andreas Bikfalvi ,  Gerard Deleris

IPC分类号： A61K38/00 ,  A61B5/055

CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K7/08 ,  C07K7/64

摘要： The invention relates to cyclopeptides, the method of their preparation and their utilization as inhibitors or activators of angiogenesis.These cyclopeptides comprise the following peptide sequence: -Arg-Ile-Lys-Pro-His-Gln-Gly- They can be used in systems for inhibition of angiogenesis that comprises a support (1), to which the cyclopeptide is affixed by means of an organic spacer arm (3) that may be provided with a moiety (4) capable of being spliced by an enzyme system.

摘要翻译： 本发明涉及环肽，其制备方法及其作为血管生成抑制剂或活化剂的用途。

公开(公告)号：US06517858B1

公开(公告)日：2003-02-11

申请号：US09831948

申请日：2001-05-16

申请人： Alain Le Moel ,  Natacha Betz ,  Christophe Bureau ,  Guy Deniau ,  Charles Baquey ,  Gérard Deleris ,  Werner Haberbosch

发明人： Alain Le Moel ,  Natacha Betz ,  Christophe Bureau ,  Guy Deniau ,  Charles Baquey ,  Gérard Deleris ,  Werner Haberbosch

IPC分类号： A61F200

CPC分类号： A61L33/0029 ,  A61F2/06 ,  A61F2/82 ,  A61L27/28 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2400/18

摘要： The invention relates to a bioactive implant comprising a substrate coated with a polymer layer with reactive functions, and a bioactive substance fixed on the implant by means of said reactive functions to enable progressive release on the implant site. Such implants are useful in the field of cardiology for example to prevent restenosis resulting from the fitting of stents in the coronary arteries.

摘要翻译： 本发明涉及生物活性植入物，其包括涂覆有具有反应性功能的聚合物层的基底，以及通过所述反应性功能固定在植入物上的生物活性物质，以使得能够在植入物位点逐渐释放。这种植入物在 心脏病学例如用于预防冠状动脉支架装配引起的再狭窄。