公开(公告)号：US07494992B2

公开(公告)日：2009-02-24

申请号：US10777713

申请日：2004-02-12

申请人： Nathan A. Chubb ,  Douglas J. Critcher ,  James J. Eshelby ,  Graham Lunn ,  Andrew J. Rudge ,  Nigel D. Walshe ,  Paul H Wiedenau ,  David H. Williams

发明人： Nathan A. Chubb ,  Douglas J. Critcher ,  James J. Eshelby ,  Graham Lunn ,  Andrew J. Rudge ,  Nigel D. Walshe ,  Paul H Wiedenau ,  David H. Williams

IPC分类号： C07D491/04 ,  A61K31/5365

CPC分类号： C07D498/04

摘要： The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic formulation.More particularly, the present invention relates to derivatives of the terpene alkaloid (1S,2R,4aS,5R,8R,8aR)-2-(acetyloxy)-8a-hydroxy-3,8-dimethyl-5-(1-methylethenyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate. Pharmaceutical compositions comprising the same are also disclosed.

摘要翻译： 本发明涉及新颖的萜烯生物碱及其作为抗寄生虫剂的用途。 本发明还涉及一种抗寄生虫剂，其包含本发明的萜烯生物碱化合物作为抗寄生虫制剂中的有效成分。 更具体地说，本发明涉及萜烯生物碱（1S，2R，4aS，5R，8R，8aR）-2-（乙酰氧基）-8a-羟基-3,8-二甲基-5-（1-甲基乙烯基） -1,2,4a，5,6,7,8,8a-八氢萘-1-基（2S，3aR，9bR）-6-氯-9β-羟基-5-甲基-1,2,3,3a， 5,9b-六氢吡咯并[2,3-c] [2,1]苯并恶嗪-2-羧酸乙酯。 还公开了包含其的药物组合物。