公开(公告)号：US08207222B2

公开(公告)日：2012-06-26

申请号：US12707410

申请日：2010-02-17

Applicant: Tilak Raj Bhardwaj ,  Manoj Kumar ,  Necraj Mehta ,  Neelima Dhingra

Inventor： Tilak Raj Bhardwaj ,  Manoj Kumar ,  Necraj Mehta ,  Neelima Dhingra

IPC: C07C203/04 ,  A61K31/167

CPC classification number: C07C233/25

Abstract: The present invention particularly relates to novel nitrate esters of paracetamol. The nitrate esters of paracetamol are prepared by reacting the paracetamol with dihaloalkyl compound and followed by reaction with silver nitrate to obtain the corresponding nitrate ester derivatives. The nitrate esters of paracetamol are useful as analgesic, anti-inflammatory agents.

Abstract translation: 本发明特别涉及新型的扑热息痛的硝酸酯。 对乙酰氨基酚的硝酸酯通过使对乙酰氨基酚与二卤烷基化合物反应，随后与硝酸银反应得到相应的硝酸酯衍生物。 对乙酰氨基酚的硝酸酯可用作止痛剂，抗炎剂。