公开(公告)号：US07067143B2

公开(公告)日：2006-06-27

申请号：US09945374

申请日：2001-08-31

申请人： Mark J. Doty ,  Christine L. Rebbeck ,  James E. Kipp ,  Neervalur V. Raghavan

发明人： Mark J. Doty ,  Christine L. Rebbeck ,  James E. Kipp ,  Neervalur V. Raghavan

IPC分类号： A61K9/00 ,  A61K9/08

CPC分类号： A61K9/0019 ,  A61K31/343 ,  A61K47/26

摘要： A premix parenteral solution for intravenous administration having amiodarone, as an active ingredient, solubilized in a solution of water for injection and about 0.4-12 mg/ml of a non-ionic surfactant to a concentration range of from 0.2 to 6 mg/ml is disclosed. The solution optionally may include an osmotic agent. No dilution of the solution is required before administering to a patient and the sterile packaged solution has an initial pH within the range of from about 2.9 to about 3.2, preferably about 3.1. Additionally, a method for producing an amiodarone solution suitable for intravenous administration is further disclosed.