公开(公告)号：US08859824B2

公开(公告)日：2014-10-14

申请号：US12651927

申请日：2010-01-04

申请人： Mary Ann Walter ,  Jian Gao ,  Neill Bailey Walsdorf

发明人： Mary Ann Walter ,  Jian Gao ,  Neill Bailey Walsdorf

IPC分类号： C07C43/30 ,  A61K31/075 ,  A61K31/19 ,  A61K31/194 ,  C07C59/265

CPC分类号： A61K31/194 ,  C07C59/265

摘要： Compounds are provided herein which are coordination complexes of the formula, AxByCit2Fz.mH2O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table; B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions; A and B are different; “Cit” is tribasic citric acid anion; the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0; m is 0-12; and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.

摘要翻译： 本文提供了下式的配位络合物：AxByCit2Fz.mH2O，其中A是选自元素周期表中某些IA或IIA金属离子的阳离子; B是选自某些IIA金属离子和某些二价d嵌段过渡金属离子的阳离子; A和B不同; “Cit”是三元柠檬酸阴离子; x与y的化学计量比等于或高于1.0但低于8.0; m为0-12; 并且z被选择使得保持电中性。 本文提供的化合物可用于治疗饮食缺乏症，骨质疏松症，骨质减少，骨质流失和骨质流失的风险，以及涉及需要给予各种离子的其它医学病症。 此外，这些化合物可用作牙科用途的氟化物源，并且用于氟化水系统。

公开(公告)号：US20100184866A1

公开(公告)日：2010-07-22

申请号：US12651927

申请日：2010-01-04

申请人： Mary Ann Walter ,  Jian Gao ,  Neill Bailey Walsdorf

发明人： Mary Ann Walter ,  Jian Gao ,  Neill Bailey Walsdorf

IPC分类号： A61K31/09 ,  C07C43/30

CPC分类号： A61K31/194 ,  C07C59/265

摘要： Compounds are provided herein which are coordination complexes of the formula, AxByCit2Fz.mH2O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table; B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions; A and B are different; “Cit” is tribasic citric acid anion; the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0; m is 0-12; and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.

摘要翻译： 本文提供了下式的配位络合物：AxByCit2Fz.mH2O，其中A是选自元素周期表中某些IA或IIA金属离子的阳离子; B是选自某些IIA金属离子和某些二价d嵌段过渡金属离子的阳离子; A和B不同; “Cit”是三元柠檬酸阴离子; x与y的化学计量比等于或高于1.0但低于8.0; m为0-12; 并且z被选择使得保持电中性。 本文提供的化合物可用于治疗饮食缺乏症，骨质疏松症，骨质减少，骨质流失和骨质流失的风险，以及涉及需要给予各种离子的其它医学病症。 此外，这些化合物可用作牙科用途的氟化物源，并且用于氟化水系统。