公开(公告)号：US06733789B1

公开(公告)日：2004-05-11

申请号：US09488103

申请日：2000-01-20

申请人： Paul Stark ,  Catherine Mary Kelly ,  Niall M. Fanning

发明人： Paul Stark ,  Catherine Mary Kelly ,  Niall M. Fanning

IPC分类号： A61K916

CPC分类号： A61K9/5078 ,  A61K9/5026 ,  A61K31/138

摘要： A multiparticulate bisoprolol formulation for once-daily oral administration, each particle of which comprises a core of bisoprolol or a pharmaceutically acceptable salt thereof surrounded by a polymeric coating, the polymeric coating being effective to achieve an initial lag of bisoprolol release in vivo of at least 4-6 hours following administration and thereafter maintaining therapeutic concentrations of bisoprolol for the remainder of the twenty-four hour period. The formulation can be used for night-time dosing so as to minimize the likelihood of acute cardiovascular occurrences in the well-documented high risk period in the morning.

摘要翻译： 一种每日一次的口服给药的多颗粒比索洛尔制剂，其每个颗粒包含由聚合物涂层包围的比索洛尔核心或其药学上可接受的盐，所述聚合物涂层有效地达到至少在体内释放比索洛尔的初始滞留 给药后4-6小时，然后在二十四小时的剩余时间内维持比索洛尔的治疗浓度。 该制剂可用于夜间给药，以便在早晨记录良好的高危时期内尽量减少急性心血管事件发生的可能性。