公开(公告)号：US4049816A

公开(公告)日：1977-09-20

申请号：US666662

申请日：1976-03-15

申请人： Michael Raymond Harnden ,  Nicholas David Wright

发明人： Michael Raymond Harnden ,  Nicholas David Wright

IPC分类号： C07D417/06 ,  C07D209/18 ,  C07D275/02

CPC分类号： C07D209/18

摘要： Thiazolinone analogues of indolmycin having anti-viral activity as well as a degree of antibacterial and antimycoplasmal activity in contrast to the known indolmycin which has only some antibacterial activity. Tautomers and a single enantiomer or mixture of enantiomers are included. Intermediates are described which are cyclized to produce the active antiviral substances. Suitable dosage forms and amounts are set forth and various routes of administration included including administration to the respiratory tract as by insufflation or inhalation.

摘要翻译： 具有抗病毒活性的吲哚霉素的噻唑啉酮类似物以及与仅具有一些抗菌活性的已知的吲哚霉素相反的一定程度的抗细菌和抗支原体活性。 包括Tautomers和单一对映异构体或对映异构体混合物。 描述了环化以产生活性抗病毒物质的中间体。 阐述合适的剂量形式和量，并包括各种给药途径，包括通过吹入或吸入给予呼吸道。