公开(公告)号：US08138188B2

公开(公告)日：2012-03-20

申请号：US12280444

申请日：2007-02-19

申请人： Mark David Andrews ,  Alan Daniel Brown ,  Mark Ian Lansdell ,  Nicholas William Summerhill

发明人： Mark David Andrews ,  Alan Daniel Brown ,  Mark Ian Lansdell ,  Nicholas William Summerhill

IPC分类号： C07D401/14 ,  A61K31/4402 ,  A61P15/00 ,  A61P3/00

CPC分类号： C07D401/14

摘要： The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

摘要翻译： 本发明涉及一类通式（I）的黑皮质素MCR4激动剂，其中变量和取代基如本文所定义，特别是选择性MCR4激动剂化合物在医学中的用途，特别是用于治疗性功能障碍和肥胖症， 可用于其合成的中间体和含有它们的组合物。

公开(公告)号：US20090036459A1

公开(公告)日：2009-02-05

申请号：US12280444

申请日：2007-02-19

申请人： Mark David Andrews ,  Alan Daniel Brown ,  Mark Ian Lansdell ,  Nicholas William Summerhill

发明人： Mark David Andrews ,  Alan Daniel Brown ,  Mark Ian Lansdell ,  Nicholas William Summerhill

IPC分类号： A61K31/501 ,  C07D401/14 ,  A61P3/00 ,  A61K31/4545

CPC分类号： C07D401/14

摘要： The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) wherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

摘要翻译： 本发明涉及一类通式（I）的黑皮质素MCR4激动剂，其中变量和取代基如本文所定义，特别是选择性MCR4激动剂化合物在医学中的用途，特别是用于治疗性功能障碍和肥胖症， 可用于其合成的中间体和含有它们的组合物。