公开(公告)号：US08383336B2

公开(公告)日：2013-02-26

申请号：US12996143

申请日：2009-07-13

申请人： Thomas K. Hayes ,  Nicole D. Krilla ,  Lori Nixon

发明人： Thomas K. Hayes ,  Nicole D. Krilla ,  Lori Nixon

IPC分类号： C12Q1/68

CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/335 ,  C12N2310/3525

摘要： A room temperature stable and minimal aggregate liquid formulation comprises an oligonucleotide comprising Seq ID No. 1: or comprising a variant oligonucleotide in which no more than 3 non-sequential bases are different from Seq. ID NO. 1 and an aqueous carrier comprising a aggregation-preventing compound selected from the group consisting of mono and disaccharides and/or sugar alcohols.

摘要翻译： 室温稳定和最小的骨液制剂包含含有Seq ID No.1的寡核苷酸，或包含其中不超过3个非顺序碱基不同于Seq的变体寡核苷酸。 证件号码。 1和包含选自单糖和二糖和/或糖醇的聚集体防止化合物的水性载体。

公开(公告)号：US20110098343A1

公开(公告)日：2011-04-28

申请号：US12996143

申请日：2009-07-13

申请人： Thomas K. Hayes ,  Nicole D. Krilla ,  Lori Nixon

发明人： Thomas K. Hayes ,  Nicole D. Krilla ,  Lori Nixon

IPC分类号： A61K31/7088

CPC分类号： C12N15/113 ,  A61K31/713 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/335 ,  C12N2310/3525

摘要： A room temperature stable and minimal aggregate liquid formulation comprises an oligonucleotide comprising Seq ID No. 1: or comprising a variant oligonucleotide in which no more than 3 non-sequential bases are different from Seq. ID NO. 1 and an aqueous carrier comprising a aggregation-preventing compound selected from the group consisting of mono and disaccharides and/or sugar alcohols.

摘要翻译： 室温稳定和最小的骨液制剂包含含有Seq ID No.1的寡核苷酸，或包含其中不超过3个非顺序碱基不同于Seq的变体寡核苷酸。 证件号码。 1和包含选自单糖和二糖和/或糖醇的聚集体防止化合物的水性载体。