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![12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME](/abs-image/US/2018/07/05/US20180185325A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180185325A1
公开(公告)日：2018-07-05
申请号：US15739441
申请日：2016-06-08
申请人： Nigel Robert Arnold Beeley , Howard Glenn Welgus , Jay Edward Birnbaum , J. Gordon Foulkes , Celia Patricia Jenkinson , Jean Hilaire Saurat
发明人： Nigel Robert Arnold Beeley , Howard Glenn Welgus , Jay Edward Birnbaum , J. Gordon Foulkes , Celia Patricia Jenkinson , Jean Hilaire Saurat
CPC分类号： A61K31/352 , A61K9/0014 , A61K31/357 , A61K31/36 , A61K2300/00 , A61P17/08 , A61P17/10 , A61P27/02 , A61P35/00
摘要： The present invention provides compounds of the following structure, methods of using such compounds, and pharmaceutical compositions containing such compounds. In addition, this invention provides methods for the treatment and/or prevention of disease states mediated by Aryl Hydrocarbon receptor pathways.
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![12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME](/abs-image/US/2018/06/28/US20180179174A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180179174A1
公开(公告)日：2018-06-28
申请号：US15739451
申请日：2016-06-06
申请人： Nigel Robert Arnold Beeley , Howard Glenn Welgus , Jay Edward Birnbaum , J. Gordon Foulkes , Celia Patricia Jenkinson , Jean Hilaire Saurat
发明人： Nigel Robert Arnold Beeley , Howard Glenn Welgus , Jay Edward Birnbaum , J. Gordon Foulkes , Celia Patricia Jenkinson , Jean Hilaire Saurat
IPC分类号： C07D311/78 , A61P17/08 , A61K9/00 , A61K31/352 , C07D493/04 , C07D493/14 , A61K31/357
CPC分类号： C07D311/78 , A61K9/0014 , A61K31/352 , A61K31/357 , A61K31/366 , A61K48/00 , A61P17/08 , C07B2200/07 , C07B2200/09 , C07D493/04 , C07D493/14
摘要： The present invention provides compounds of the following structure, methods of using such compounds, and pharmaceutical compositions containing such compounds. In addition, this invention provides methods for the treatment and/or prevention of disease states mediated by Aryl Hydrocarbon receptor pathways.
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公开(公告)号：US07960341B2
公开(公告)日：2011-06-14
申请号：US11518574
申请日：2006-09-08
IPC分类号： A61K38/22
CPC分类号： A61K45/06 , A61K38/2278 , A61K38/24 , A61K38/26 , A61K2300/00
摘要： The present invention relates to methods of treating polycystic ovary syndrome (PCOS) comprising administering glucagon-like peptide-1 (GLP-1), exendin, and analogs and agonists thereof, to subjects suffering therefrom.
摘要翻译： 本发明涉及治疗多囊卵巢综合征（PCOS）的方法，其包括向患有受试者的受试者施用胰高血糖素样肽-1（GLP-1），毒蜥外泌肽及其类似物和激动剂。
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公开(公告)号：US07858740B2
公开(公告)日：2010-12-28
申请号：US11511738
申请日：2006-08-28
IPC分类号： A61K38/16
CPC分类号： C07K14/57563 , A61K38/00
摘要： Novel exendin agonist compounds are provided. These compounds are useful in treating Type I and II diabetes and conditions which would be benefited by lower plasma glucose and delaying and/or slowing gastric emptying.
摘要翻译： 提供了新的毒蜥外泌激素化合物。 这些化合物可用于治疗I型和II型糖尿病以及通过降低血浆葡萄糖和延迟和/或减缓胃排空而受益的病症。
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公开(公告)号：US07696161B2
公开(公告)日：2010-04-13
申请号：US11807031
申请日：2007-05-25
CPC分类号： C07K14/57563 , A61K38/00
摘要： Novel exendin agonist compounds are provided. These compounds are useful in treating diabetes and conditions which would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying.
摘要翻译： 提供了新的毒蜥外泌激素化合物。 这些化合物可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空而受益的糖尿病和病症。
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公开(公告)号：US20090176704A1
公开(公告)日：2009-07-09
申请号：US12201918
申请日：2008-08-29
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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公开(公告)号：US20110071076A1
公开(公告)日：2011-03-24
申请号：US12959176
申请日：2010-12-02
CPC分类号： C07K14/57563 , A61K38/00
摘要： Novel exendin agonist compounds are provided. These compounds are useful in treating Type I and II diabetes and conditions which would benefit by lower plasma glucose and delaying and/or slowing gastric emptying.
摘要翻译： 提供了新的毒蜥外泌激素化合物。 这些化合物可用于治疗I型和II型糖尿病以及通过降低血浆葡萄糖和延迟和/或减缓胃排空而受益的病症。
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公开(公告)号：US07700549B2
公开(公告)日：2010-04-20
申请号：US12201918
申请日：2008-08-29
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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公开(公告)号：US07544690B2
公开(公告)日：2009-06-09
申请号：US10490996
申请日：2002-09-30
申请人： Yoshinori Sekiguchi , Kosuke Kanuma , Katsunori Omodera , Thuy-Anh Tran , Bryan Aubrey Kramer , Nigel Robert Arnold Beeley
发明人： Yoshinori Sekiguchi , Kosuke Kanuma , Katsunori Omodera , Thuy-Anh Tran , Bryan Aubrey Kramer , Nigel Robert Arnold Beeley
IPC分类号： C07D239/95 , C07D403/12 , A61K31/517 , A61K31/5377 , A61P3/04 , A61P25/22 , A61P25/24
CPC分类号： C07D239/95 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to novel compounds of the formula (I) which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of obesity, obesity related disorders, anxiety, or depression.
摘要翻译： 本发明涉及作为MCH受体拮抗剂的式（I）化合物。 这些组合物可用于药物组合物，其用途包括预防或治疗肥胖，肥胖相关疾病，焦虑或抑郁症。
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公开(公告)号：US07419952B2
公开(公告)日：2008-09-02
申请号：US11368225
申请日：2006-03-03
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/22 , A61K38/2207 , A61K38/2264 , A61K38/23 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/57563 , Y10S514/866 , A61K2300/00
摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。
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