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    Benzisoxazole derivatives
    1.
    发明授权
    Benzisoxazole derivatives 有权
    苯并异恶唑衍生物

    公开(公告)号：US08816090B2

    公开(公告)日：2014-08-26

    申请号：US11814588

    申请日：2006-02-15

    申请人： Hirohide Noguchi ,  Isao Sakurada ,  Chikara Uchida ,  Nobuaki Waizumi

    发明人： Hirohide Noguchi ,  Isao Sakurada ,  Chikara Uchida ,  Nobuaki Waizumi

    IPC分类号： C07D261/20 ,  A61K31/4439

    CPC分类号： C07D413/12 ,  C07D413/14

    摘要： This invention relates to compounds of the formula (I): wherein A, B, R1, R4, m, and n are each as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central 10 nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）的化合物：其中A，B，R 1，R 4，m和n各自如本文所述或其药学上可接受的盐，以及含有这些化合物的组合物和这些化合物在 治疗由5-HT4受体活性介导的病症，例如但不限于胃食管反流病，胃肠道疾病，胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎 ，胃肠疾病，恶心，中枢10神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛，心力衰竭和心律失常等心血管疾病，糖尿病和呼吸暂停综合征。

    Polymorph Form of 4-methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylic acid
    2.
    发明申请
    Polymorph Form of 4-methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylic acid 有权
    4-甲基）哌啶-1-基]甲基} - 四氢-2H-吡喃-4-羧酸的多晶型

    公开(公告)号：US20140187583A1

    公开(公告)日：2014-07-03

    申请号：US14118377

    申请日：2012-05-18

    申请人： Toyoharu Numata ,  Hirohide Noguchi ,  Nobuaki Waizumi ,  Takashi Kojima

    发明人： Toyoharu Numata ,  Hirohide Noguchi ,  Nobuaki Waizumi ,  Takashi Kojima

    IPC分类号： C07D413/14

    CPC分类号： C07D413/14

    摘要： The present invention relates to novel crystal forms of 4-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylic acid. More particularly, the invention relates to polymorph forms (Polymorph Form I or Polymorph Form II), and to processes for the preparation of, compositions containing and to uses of, such polymorph forms.

    摘要翻译： 本发明涉及4 - {[4 - （{[4-（2,2,2-三氟乙氧基）-1,2-苯并异恶唑-3-基]氧基}甲基）哌啶-1-基] 甲基} - 四氢-2H-吡喃-4-羧酸。 更具体地说，本发明涉及多晶型形式（多晶型I或多晶型II），以及制备含这种多晶型形式的组合物和使用方法。

    Benzisoxazole Derivatives
    4.
    发明申请
    Benzisoxazole Derivatives 有权
    苯并异恶唑衍生物

    公开(公告)号：US20080207690A1

    公开(公告)日：2008-08-28

    申请号：US11814588

    申请日：2006-02-15

    申请人： Hirohide Noguchi ,  Isao Sakurada ,  Chikara Uchida ,  Nobuaki Waizumi

    发明人： Hirohide Noguchi ,  Isao Sakurada ,  Chikara Uchida ,  Nobuaki Waizumi

    IPC分类号： A61K31/454 ,  C07D401/12 ,  A61P1/04 ,  C07D401/14

    CPC分类号： C07D413/12 ,  C07D413/14

    摘要： This invention relates to compounds of the formula (I): wherein A, B, R1, R4, m, and n are each as described herein or a pharmaceutically acceptable salt thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central 10 nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.

    摘要翻译： 本发明涉及式（I）化合物：其中A，B，R 1，R 4，m和n各自如本文所述，或药学上可接受的 其盐和含有这些化合物的组合物以及这些化合物在治疗5-HT 4受体活性介导的病症中的用途，例如但不限于胃食管反流病，胃肠道疾病， 胃动力障碍，非溃疡性消化不良，功能性消化不良，肠易激综合征（IBS），便秘，消化不良，食管炎，胃食管疾病，恶心，中枢10神经系统疾病，阿尔茨海默病，认知障碍，呕吐，偏头痛，神经系统疾病，疼痛 ，心血管疾病如心力衰竭和心律失常，糖尿病和呼吸暂停综合征。