公开(公告)号：US08742127B2

公开(公告)日：2014-06-03

申请号：US12809868

申请日：2008-12-19

申请人： Nobusuke Kashiki ,  Toshiki Mori ,  Katsuji Ujita

发明人： Nobusuke Kashiki ,  Toshiki Mori ,  Katsuji Ujita

IPC分类号： C07D211/72

CPC分类号： C07D213/61 ,  C07D401/04

摘要： [Problem]The present invention provides an industrially advantageous production method of a 6-halogeno-3-arylpyridine derivative in which cryogenic condition is not required, production step is short, and an isomer difficult to be separated is not produced as a by-product,[Solution]A production method of a 6-halogeno-3-arylpyridine derivative represented by the general formula (III) comprising: the first step reacting a 2,5-dihalogenopyridine derivative represented by the general formula (I) with a magnesiation reagent; and the second step reacting the product obtained from the above-described first step, in the presence of a palladium compound, with a halogenoaryl derivative represented by the general formula (II).

摘要翻译： 本发明提供了不需要低温条件的6-卤-3-芳基吡啶衍生物的工业上有利的制备方法，制备步骤短，难以分离的异构体不作为副产物产生 ，[溶液]由通式（III）表示的6-卤代-3-芳基吡啶衍生物的制备方法，包括：使通式（I）表示的2,5-二卤代吡啶衍生物与氧化试剂 ; 第二步是将由上述第一步获得的产物在钯化合物的存在下与通式（II）表示的卤代芳基衍生物进行反应。

公开(公告)号：US20100280253A1

公开(公告)日：2010-11-04

申请号：US12809868

申请日：2008-12-19

申请人： Nobusuke Kashiki ,  Toshiki Mori ,  Katsuji Ujita

发明人： Nobusuke Kashiki ,  Toshiki Mori ,  Katsuji Ujita

IPC分类号： C07D213/61

CPC分类号： C07D213/61 ,  C07D401/04

摘要： [Problem] The present invention provides an industrially advantageous production method of a 6-halogeno-3-arylpyridine derivative in which cryogenic condition is not required, production step is short, and an isomer difficult to be separated is not produced as a by-product,[Solution] A production method of a 6-halogeno-3-arylpyridine derivative represented by the general formula (III) comprising: the first step reacting a 2,5-dihalogenopyridine derivative represented by the general formula (I) with a magnesiation reagent; and the second step reacting the product obtained from the above-described first step, in the presence of a palladium compound, with a halogenoaryl derivative represented by the general formula (II).

摘要翻译： 本发明提供了不需要低温条件的6-卤-3-芳基吡啶衍生物的工业上有利的制备方法，制备步骤短，难以分离的异构体不作为副产物产生 ，[溶液]由通式（III）表示的6-卤代-3-芳基吡啶衍生物的制备方法，包括：使通式（I）表示的2,5-二卤代吡啶衍生物与氧化试剂 ; 第二步是将由上述第一步获得的产物在钯化合物的存在下与通式（II）表示的卤代芳基衍生物进行反应。