公开(公告)号：US20240018548A1

公开(公告)日：2024-01-18

申请号：US18452495

申请日：2023-08-18

Applicant: Lucie CARRIER ,  Thomas ESCHENHAGEN ,  Thomas VOIT ,  Giulia MEARINI ,  Oliver MUELLER ,  Doreen STIMPEL

Inventor： Lucie CARRIER ,  Thomas ESCHENHAGEN ,  Thomas VOIT ,  Giulia MEARINI ,  Oliver MUELLER ,  Doreen STIMPEL ,  Julia MOUROT-FILIATRE

IPC: C12N15/86 ,  C07K14/47 ,  A61K48/00 ,  A61P9/00

CPC classification number: C12N15/86 ,  C07K14/4716 ,  A61K48/0058 ,  A61K48/0066 ,  A61P9/00

Abstract: The present invention relates to a gene therapy vector which is useful in the treatment or prevention of hypertrophic cardiomyopathy in a subject in need thereof. The gene therapy vector of the invention comprises a nucleic acid sequence encoding a cardiac sarcomeric protein and a cardiomyocyte-specific promoter which is operably linked to said nucleic acid sequence. The invention furthermore relates to a cell which comprises the gene therapy vector. Pharmaceutical compositions which comprise the gene therapy vector and/or a cell comprising said vector are also provided. In another aspect, the invention relates to a method for treating or preventing hypertrophic cardiomyopathy in a subject by introducing the gene therapy vector of the invention into a subject in need of treatment.

公开(公告)号：US20120202732A1

公开(公告)日：2012-08-09

申请号：US13322121

申请日：2010-05-28

Applicant: Oliver Mueller ,  Hugo Katus ,  Karl Varadi ,  Jürgen Kleinschmidt

Inventor： Oliver Mueller ,  Hugo Katus ,  Karl Varadi ,  Jürgen Kleinschmidt

IPC: A61K38/02 ,  C12P21/02 ,  C12N5/10 ,  A61P9/00 ,  A61K31/713 ,  C07K14/075 ,  C07K16/08 ,  C12N15/34 ,  G01N33/53 ,  C12N15/85

CPC classification number: C07K14/005 ,  C12N2710/24143 ,  C12N2750/14122 ,  C12N2810/40

Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.

Abstract translation: 本发明涉及编码包含插入肽和包含所述多核苷酸的载体的AAV衣壳多肽的多核苷酸。 此外，预期包含所述多核苷酸或载体的宿主细胞，制备所述衣壳多肽的方法以及所述多肽。 进一步包括与所述多肽特异性结合的抗体和包含所述多核苷酸，载体，多肽或抗体的药物。 还考虑了所述多核苷酸，载体，多肽或抗体在制备用于治疗血管疾病的药物中的用途以及用于鉴定与所述多肽结合的化合物的方法。

公开(公告)号：US20110290358A1

公开(公告)日：2011-12-01

申请号：US13115136

申请日：2011-05-25

Applicant: Andriy Bitman ,  Oliver Mueller-Marc ,  Dieter Jerosch

Inventor： Andriy Bitman ,  Oliver Mueller-Marc ,  Dieter Jerosch

IPC: F15C1/06

CPC classification number: G09F9/372 ,  G02B26/004 ,  Y10T137/206

Abstract: A device for displaying information comprising at least one display element which includes: a liquid, the surface energy thereof being variable by means of an electric field; a first and a second volume for receiving the liquid, wherein said first and said second volume are defined by a first effective radius or a second effective radius, respectively, a fluidic passage between said first and said second volume, wherein in a first state said liquid substantially occupies said first volume and wherein in a second state said liquid substantially occupies said second volume, is characterized in that said passage is configured such that the fraction of the liquid facing to the unoccupied volume comprises a radius which is smaller than the effective radius of the presently occupied volume.

Abstract translation: 一种用于显示包括至少一个显示元件的信息的装置，包括：液体，其表面能通过电场而变化; 用于接收液体的第一和第二容积，其中所述第一和所述第二容积分别由第一有效半径或第二有效半径限定在所述第一和所述第二体积之间的流体通道，其中在第一状态中所述 液体基本上占据所述第一容积，并且其中在第二状态下，所述液体基本上占据所述第二容积，其特征在于，所述通道被配置为使得面向未占据体积的液体的部分包括小于有效半径的半径 的占用量。

公开(公告)号：US20110235158A1

公开(公告)日：2011-09-29

申请号：US13053278

申请日：2011-03-22

Applicant: Oliver Mueller-Marc ,  Dieter Jerosch ,  Andriy Bitman ,  Frank Bartels

Inventor： Oliver Mueller-Marc ,  Dieter Jerosch ,  Andriy Bitman ,  Frank Bartels

IPC: G02B26/00

CPC classification number: G02B26/005 ,  G02B5/22

Abstract: The invention relates to a display device having at least one electrically controllable display element comprising a first and at least one further liquid, a plurality of fluidically closed volumes and at least one voltage source which is connected to an electrode array, wherein said volumes include flat visible subvolumes which stacked upon another along their shortest dimension, having associated second subvolumes which pass through those flat visible subvolumes which are underlying that flat visible subvolume which is associated with the respective second subvolume.

Abstract translation: 本发明涉及一种具有至少一个电可控显示元件的显示装置，该显示元件包括第一和至少一个另外的液体，多个流体封闭的体积和连接到电极阵列的至少一个电压源，其中所述体积包括平坦 其沿着其最短尺寸堆叠在另一个上的可见子体积具有相关联的第二子体积，其通过与相应的第二子体积相关联的平坦可见子体的那些平坦的可见子体积。

公开(公告)号：US20110235157A1

公开(公告)日：2011-09-29

申请号：US13052403

申请日：2011-03-21

Applicant: Oliver Mueller-Marc ,  Dieter Jerosch ,  Andriy Bitman ,  Frank Bartels

Inventor： Oliver Mueller-Marc ,  Dieter Jerosch ,  Andriy Bitman ,  Frank Bartels

IPC: G02B26/00

CPC classification number: G02B26/004 ,  G09G3/2003 ,  G09G3/348

Abstract: The invention relates to a display device having at least one electronically controllable display element comprising at least one non-polar and at least two electrically conducting or polar liquids, a fluidically closed volume having a visible subvolume, a further subvolume and at least two storage volumes connected to said subvolumes, as well as a voltage source connected to a first electrode array. It is provided thereby that each of said electrically conducting or polar liquids assumes a volume which is dimensioned such that, independent of application of voltage to the electrode array, always a fluidically tight closure for non-polar liquid between the respective storage volume and either the visible or the further subvolume is formed.

Abstract translation: 本发明涉及具有至少一个电子可控显示元件的显示装置，该显示元件包括至少一个非极性和至少两个导电或极性液体，具有可见子体积的流体封闭体积，另外的子体积和至少两个存储体积 连接到所述子体积，以及连接到第一电极阵列的电压源。 由此提供每个所述导电或极性液体的体积，其体积尺寸使得不依赖于对电极阵列的电压的施加，对于非极性液体，在相应的存储容积和 可见或形成另外的子体积。

公开(公告)号：US20100123946A1

公开(公告)日：2010-05-20

申请号：US12612758

申请日：2009-11-05

Applicant: Oliver Mueller-Marc ,  Andriy Bitman

Inventor： Oliver Mueller-Marc ,  Andriy Bitman

IPC: G02B26/00 ,  G06F3/038 ,  G09G5/02

CPC classification number: G09F9/372 ,  G02B26/004 ,  G02B26/0833 ,  G09F19/16

Abstract: The invention relates to a display element for the display of a plurality of a colors and a method for their display.For this purpose, the invention teaches a display element 1 based on one or more color-producing surfaces 2 which can be oriented parallel to the viewing direction 3 of an observer, for example, so that the observer views only the narrow edges of the surfaces 2. The actual content is perceptible only because a movable reflector 4 is also provided in which the color-producing surface 2 is reflected.The display element claimed by the invention has a particularly good aperture. In the case of static images, the power consumption of the display element is very low. In one preferred embodiment, the display element also makes possible the presentation of a large color space and can be independent of the presence of ambient light.

Abstract translation: 本发明涉及用于显示多种颜色的显示元件及其显示方法。 为此，本发明教导了基于一个或多个产生表面2的显示元件1，其可以平行于观察者的观察方向3定向，使得观察者仅观察表面的窄边缘 实际的内容是可见的，因为也可以提供可反射的反射器4，其中产生颜色的表面2被反射。 本发明所要求保护的显示元件具有特别好的孔径。 在静态图像的情况下，显示元件的功耗非常低。 在一个优选实施例中，显示元件还可以呈现大的颜色空间并且可以独立于环境光的存在。

公开(公告)号：US08520289B2

公开(公告)日：2013-08-27

申请号：US12612758

申请日：2009-11-05

Applicant: Oliver Mueller-Marc ,  Andriy Bitman

Inventor： Oliver Mueller-Marc ,  Andriy Bitman

IPC: G02B26/00

CPC classification number: G09F9/372 ,  G02B26/004 ,  G02B26/0833 ,  G09F19/16

Abstract: The invention relates to a display element for the display of a plurality of a colors and a method for their display.For this purpose, the invention teaches a display element 1 based on one or more color-producing surfaces 2 which can be oriented parallel to the viewing direction 3 of an observer, for example, so that the observer views only the narrow edges of the surfaces 2. The actual content is perceptible only because a movable reflector 4 is also provided in which the color-producing surface 2 is reflected.The display element claimed by the invention has a particularly good aperture. In the case of static images, the power consumption of the display element is very low. In one preferred embodiment, the display element also makes possible the presentation of a large color space and can be independent of the presence of ambient light.

Abstract translation: 本发明涉及用于显示多种颜色的显示元件及其显示方法。 为此，本发明教导了基于一个或多个产生表面2的显示元件1，其可以平行于观察者的观察方向3定向，使得观察者仅观察表面的窄边缘 实际的内容是可见的，因为也可以提供可反射的反射器4，其中产生颜色的表面2被反射。 本发明所要求保护的显示元件具有特别好的孔径。 在静态图像的情况下，显示元件的功耗非常低。 在一个优选实施例中，显示元件还可以呈现大的颜色空间并且可以独立于环境光的存在。

公开(公告)号：US08476418B2

公开(公告)日：2013-07-02

申请号：US13322121

申请日：2010-05-28

Applicant: Oliver Mueller ,  Hugo Katus ,  Karl Varadi ,  Jürgen Kleinschmidt

Inventor： Oliver Mueller ,  Hugo Katus ,  Karl Varadi ,  Jürgen Kleinschmidt

IPC: A61K38/02 ,  A61K9/50

CPC classification number: C07K14/005 ,  C12N2710/24143 ,  C12N2750/14122 ,  C12N2810/40

Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.

Abstract translation: 本发明涉及编码包含插入肽和包含所述多核苷酸的载体的AAV衣壳多肽的多核苷酸。 此外，预期包含所述多核苷酸或载体的宿主细胞，制备所述衣壳多肽的方法以及所述多肽。 进一步包括与所述多肽特异性结合的抗体和包含所述多核苷酸，载体，多肽或抗体的药物。 还考虑了所述多核苷酸，载体，多肽或抗体在制备用于治疗血管疾病的药物中的用途以及用于鉴定与所述多肽结合的化合物的方法。

公开(公告)号：US08462422B2

公开(公告)日：2013-06-11

申请号：US13036237

申请日：2011-02-28

Applicant: Oliver Mueller-Marc ,  Frank Bartels ,  Karlheinz Blankenbach ,  Juergen Rawert ,  Andriy Bitman ,  Dieter Jerosch

Inventor： Oliver Mueller-Marc ,  Frank Bartels ,  Karlheinz Blankenbach ,  Juergen Rawert ,  Andriy Bitman ,  Dieter Jerosch

IPC: G02B26/00

CPC classification number: G02B26/005

Abstract: The invention relates to a security element including at least one display element for non-resettable visible display of information, wherein said display element comprises a first and a second volume which are fluidically connected via at least one duct, and only one electrically controllable electrode which is associated to one of said volumes and is configured, when charged with an electric voltage, to vary the surface tension of a liquid which is present in said associated volume, wherein said liquid comprises at least an electrically conducting and/or polar and a non-polar fraction, and at least said electrically conducting fraction being completely and in a stable manner provided in that of both volumes which is not associated with an electrode and wherein said electrically conducting and/or polar fraction may be moved irreversibly and at least partly due to a single charging of the electrode into the volume which is associated with an electrode.

Abstract translation: 本发明涉及一种安全元件，其包括用于不可复位的可视显示信息的至少一个显示元件，其中所述显示元件包括经由至少一个管道流体连接的第一和第二体积，以及仅一个电可控电极， 与所述体积中的一个相关联并且被配置为当充电电压时改变存在于所述相关体积中的液体的表面张力，其中所述液体至少包括导电和/或极性和非极性 并且至少所述导电部分是完全的并且以与电极不相关的两个体积的稳定方式提供，并且其中所述导电和/或极性部分可以不可逆地移动并且至少部分地由于 将电极单个充电到与电极相关联的体积中。

公开(公告)号：US20110216391A1

公开(公告)日：2011-09-08

申请号：US13036237

申请日：2011-02-28

Applicant: Oliver Mueller-Marc ,  Frank Bartels ,  Karlheinz Blankenbach ,  Juergen Rawert ,  Andriy Bitman ,  Dieter Jerosch

Inventor： Oliver Mueller-Marc ,  Frank Bartels ,  Karlheinz Blankenbach ,  Juergen Rawert ,  Andriy Bitman ,  Dieter Jerosch

IPC: G02B26/00

CPC classification number: G02B26/005

Abstract: The invention relates to a security element including at least one display element for non-resettable visible display of information, wherein said display element comprises a first and a second volume which are fluidically connected via at least one duct, and only one electrically controllable electrode which is associated to one of said volumes and is configured, when charged with an electric voltage, to vary the surface tension of a liquid which is present in said associated volume, wherein said liquid comprises at least an electrically conducting and/or polar and a non-polar fraction, and at least said electrically conducting fraction being completely and in a stable manner provided in that of both volumes which is not associated with an electrode and wherein said electrically conducting and/or polar fraction may be moved irreversibly and at least partly due to a single charging of the electrode into the volume which is associated with an electrode.

Abstract translation: 本发明涉及一种安全元件，其包括用于不可复位的可视显示信息的至少一个显示元件，其中所述显示元件包括经由至少一个管道流体连接的第一和第二体积，以及仅一个电可控电极， 与所述体积中的一个相关联并且被配置为当充电电压时改变存在于所述相关体积中的液体的表面张力，其中所述液体至少包括导电和/或极性和非极性 并且至少所述导电部分是完全的并且以与电极不相关的两个体积的稳定方式提供，并且其中所述导电和/或极性部分可以不可逆地移动并且至少部分地由于 将电极单个充电到与电极相关联的体积中。