公开(公告)号：US06310202B1

公开(公告)日：2001-10-30

申请号：US09423363

申请日：2000-01-11

申请人： Alain Tabard ,  Olivier Siri ,  Panayotis Cocolios ,  Roger Guilard

发明人： Alain Tabard ,  Olivier Siri ,  Panayotis Cocolios ,  Roger Guilard

IPC分类号： C07D25502

CPC分类号： C07F15/045 ,  C07F15/025

摘要： Novel compounds capable of carrying and releasing nitrogen oxide (NO) in a biological medium, their use for implementing a therapeutic treatment method or a diagnostic method applied to a human or animal body, and for making medicines useful for treating or preventing disorders affecting the human or animal cardiovascular, nervous, immune, renal or pulmonary system, specifically, an organometallic complex of nitrogen oxide, wherein the cationic part is of the formula (I) in which x=0 or 1; x′=2 or 3; y=0, 2 or 3; z=0 or 1; with the condition that, if y=0 (or z=0) then z=0 (or y=0; respectively); R is a group chosen from the group formed by: a hydrogen atom, —(CH2)2COOH and R1, R2, R3 and R4 are groups chosen from the group formed by: a hydrogen atom and alkyl groups comprising from 1 to 4 carbon atoms; and M2+ is a divalent cation Fe++ or Co++.

摘要翻译： 能够在生物培养基中携带和释放氮氧化物（NO）的新型化合物，其用于实施治疗方法或应用于人体或动物体的诊断方法，以及用于制备治疗或预防影响人类的病症的药物 或动物心血管，神经，免疫，肾或肺系统，特别是氮氧化物的有机金属络合物，其中阳离子部分为式（I），其中x = 0或1; x'= 2或3; y = 0 2或3; z = 0或1;条件是，如果y = 0（或z = 0），则z = 0（或分别为y = 0）; R为选自以下的基团： 氢原子， - （CH 2）2 COOH和R 1，R 2，R 3和R 4是选自由氢原子和含有1至4个碳原子的烷基形成的基团; 和M2 +是二价阳离子Fe ++或Co ++。