公开(公告)号：US09464322B2

公开(公告)日：2016-10-11

申请号：US13608596

申请日：2012-09-10

申请人： Philip W. Landfield ,  John Christopher Gant ,  Eric M. Blalock ,  Kuey-Chu Chen ,  Olivier Thibault ,  Nada Porter

发明人： Philip W. Landfield ,  John Christopher Gant ,  Eric M. Blalock ,  Kuey-Chu Chen ,  Olivier Thibault ,  Nada Porter

IPC分类号： A61K48/00 ,  C12Q1/68 ,  A61K38/17 ,  A61K38/52

CPC分类号： C12Q1/6883 ,  A61K38/1709 ,  A61K38/1738 ,  A61K38/52 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y502/01008

摘要： The subject technology relates, in part, to a method of treating Alzheimer's Disease (AD), early-stage AD, elevated risk of AD, mild cognitive impairment (MCI), or other forms of age-related cognitive decline in a subject in need thereof by administering to the subject a molecule that promotes calcium-release stabilization in ryanodine receptors (RyRs) and/or inosital triphosphate receptors (InsP3Rs) in brain cells. Diagnostic methods using calcium-release stabilizing immunophilins, junctophilins or calmodulin are also disclosed.

摘要翻译： 主题技术部分涉及一种治疗阿尔茨海默病（AD），早期AD，升高的AD风险，轻度认知障碍（MCI）或其他形式的年龄相关的认知衰退的方法 其通过向受试者施用促进脑细胞中兰诺定受体（RyR）和/或三磷酸肌酸受体（InsP3Rs）中钙释放稳定化的分子。 还公开了使用钙释放稳定的免疫亲和素，亲油素或钙调蛋白的诊断方法。

公开(公告)号：US06354298B1

公开(公告)日：2002-03-12

申请号：US09628556

申请日：2000-07-28

申请人： Philip W. Landfield ,  Olivier Thibault

发明人： Philip W. Landfield ,  Olivier Thibault

IPC分类号： A61N100

CPC分类号： G06N3/049

摘要： A method and design is provided for distributing and storing sets of temporally ordered information in a systematic and sequential fashion. This method is based on a model of how the brain functions in the distribution and storage of temporally ordered memories, but it can also be applied to the design of new biological, electronic or optical devices. These devices may be used in the testing and development of new therapeutic drugs, in the detection of toxic agents or impaired performance, or in the development of new industrial and consumer devices in which the orderly storage of sequential information is important.

摘要翻译： 提供了一种方法和设计，用于以系统和顺序的方式分发和存储时间有序的信息集。 这种方法是基于大脑在时间有序存储器的分布和存储中的作用的模型，但也可以应用于新的生物，电子或光学器件的设计。 这些装置可用于检测和开发新的治疗药物，检测有毒物质或受损的性能，或用于开发有序存储顺序信息的新工业和消费者设备。

公开(公告)号：US06420105B1

公开(公告)日：2002-07-16

申请号：US09627082

申请日：2000-07-27

申请人： Philip W. Landfield ,  Olivier Thibault ,  Eric Blalock ,  Kuey-Chu Chen ,  Patrick Kaminker

发明人： Philip W. Landfield ,  Olivier Thibault ,  Eric Blalock ,  Kuey-Chu Chen ,  Patrick Kaminker

IPC分类号： C12Q100

CPC分类号： G01N33/5005

摘要： A method for obtaining molecules from a substantially intact single cell is disclosed. The method differs from prior methods that obtain a variable fraction of a cell's contents and therefore cannot quantitatively estimate the number of molecules in the cells. The present method comprises isolating and harvesting a substantially intact single cell from its organ tissue comprising the steps of subjecting a tissue mass to a dissociation method so that the cells are dissociated from the tissue to expose cell bodies or cell processes, contacting a dissociated cell with a device capable of collecting the cell from the tissue substantially intact, withdrawing device with the cell attached, and then isolating or detecting the molecules in the single cell.

摘要翻译： 公开了从基本完整的单电池获得分子的方法。 该方法与获得细胞内容物的可变分数的现有方法不同，因此不能定量估计细胞中的分子数。 本方法包括从其器官组织中分离和收获基本上完整的单细胞，包括以下步骤：对组织块进行解离方法，使得细胞从组织解离以暴露细胞体或细胞过程，使解离的细胞与 能够从组织基本完整地收集细胞的装置，用附着的细胞取出装置，然后分离或检测单细胞中的分子。

公开(公告)号：US07643354B2

公开(公告)日：2010-01-05

申请号：US09986290

申请日：2001-11-08

申请人： Philip W. Landfield ,  Olivier Thibault

发明人： Philip W. Landfield ,  Olivier Thibault

IPC分类号： G11C7/10

CPC分类号： G06N3/049

摘要： A method and design is provided for distributing and storing sets of temporally ordered information in a systematic and sequential fashion. This method is based on a model of how the brain functions in the distribution and storage of temporally ordered memories, but it can also be applied to the design of new biological, electronic or optical devices. These devices may be used in the testing and development of new therapeutic drugs, in the detection of toxic agents or impaired performance, or in the development of new industrial and consumer devices in which the orderly storage of sequential information is important.

摘要翻译： 提供了一种方法和设计，用于以系统和顺序的方式分发和存储时间有序的信息集。 这种方法是基于大脑在时间有序存储器的分布和存储中的作用的模型，但也可以应用于新的生物，电子或光学器件的设计。 这些装置可用于检测和开发新的治疗药物，检测有毒物质或受损的性能，或用于开发有序存储顺序信息的新工业和消费者设备。