公开(公告)号：US5574154A

公开(公告)日：1996-11-12

申请号：US315329

申请日：1994-09-29

申请人： Omar Abu-Nasrieh

发明人： Omar Abu-Nasrieh

IPC分类号： C07D501/00 ,  C07D501/06

CPC分类号： C07D501/00

摘要： The invention relates to a process for the preparation of a compound of the formula I or salts thereof ##STR1## wherein R.sub.1 is hydrogen or trityl,R.sub.2 is hydrogen, trityl, .dbd.NOCH.sub.3, .dbd.NOCH.sub.2 COOH, or .dbd.NOCCOOH(CH.sub.3).sub.2R.sub.3 is hydrogen, --CH.dbd.CH.sub.2, --CH.sub.2 COCH.sub.3, ##STR2## comprising (a) reacting a compound of the formula II ##STR3## wherein R.sub.1 and R.sub.2 are as defined above with a compound of the formula III ##STR4## wherein R.sub.3 is as defined above in the presence of a solvent; (b) refluxing the mixture in the presence of a base; and, (c) if required the compounds of the formula I so obtained are converted into salts thereof. The compounds of the formula I have antibacterial activity.

摘要翻译： 本发明涉及制备式I化合物或其盐的方法，其中R1是氢或三苯甲基，R2是氢，三苯甲基，= NOCH3，= NOCH2COOH或= NOCCOOH（CH3）2 R3是 氢，-CH = CH 2，-CH 2 COCH 3，其中R 1和R 2如上定义，其中（a）使式II化合物II与式 式III其中R 3如上所定义，在溶剂存在下; （b）在碱的存在下回流混合物; 和（c）如果需要，所得到的式I化合物被转化为其盐。 式I的化合物具有抗菌活性。