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    METHOD OF TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY BCR-ABL, C-KIT, DDR1, DDR2 OR PDGF-R KINASE ACTIVITY
    1.
    发明申请
    METHOD OF TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY BCR-ABL, C-KIT, DDR1, DDR2 OR PDGF-R KINASE ACTIVITY 有权
    BCR-ABL，C-kit，DDR1，DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的治疗方法

    公开(公告)号：US20120289528A1

    公开(公告)日：2012-11-15

    申请号：US13509626

    申请日：2010-11-17

    申请人： Neil Gallagher ,  Ophelia Yin

    发明人： Neil Gallagher ,  Ophelia Yin

    IPC分类号： A61K31/506 ,  A61P35/02 ,  A61P29/00 ,  A61P25/28 ,  A61P19/04 ,  A61P37/06 ,  A61P9/12 ,  A61P35/00 ,  A61P19/02

    CPC分类号： A61K31/506 ,  A61K9/0095 ,  C07D239/69

    摘要： The present invention relates to a regimen for the administration of a pyrimidylaminobenzamide of formula I wherein the radicals as defined herein, or of a pharmaceutically acceptable salt thereof, for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by the Bcr-Abl oncoprotein, the cell transmembrane tyrosine kinase receptor c-Kit, DDR1 (discoidin domain receptor 1), DDR2 (discoidin domain receptor 2) or PDGF-R (platelet derived growth factor receptor) kinase activity, wherein the pyrimidylaminobenzamide of formula I and, optionally, pharmaceutically acceptable carriers, are dispersed in a fruit preparation.

    摘要翻译： 本发明涉及用于施用式I嘧啶基氨基苯甲酰胺的方案，其中本文所定义的基团或其药学上可接受的盐用于治疗增殖性疾病，特别是固体和液体肿瘤，以及由其介导的其它病理学病症 Bcr-Abl癌蛋白，细胞跨膜酪氨酸激酶受体c-Kit，DDR1（盘状蛋白结构域受体1），DDR2（盘状蛋白结构域受体2）或PDGF-R（血小板衍生生长因子受体）激酶活性，其中式 I和任选的药学上可接受的载体分散在水果制剂中。

    METHOD OF TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY BCR-ABL, C-KIT, DDR1, DDR2 OR PDGF-R KINASE ACTIVITY
    2.
    发明申请
    METHOD OF TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY BCR-ABL, C-KIT, DDR1, DDR2 OR PDGF-R KINASE ACTIVITY 审中-公开
    BCR-ABL，C-kit，DDR1，DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的治疗方法

    公开(公告)号：US20140350037A1

    公开(公告)日：2014-11-27

    申请号：US14264357

    申请日：2014-04-29

    申请人： Tomasz Szczudlo ,  Richard Woodman ,  Ophelia Yin

    发明人： Tomasz Szczudlo ,  Richard Woodman ,  Ophelia Yin

    IPC分类号： C07D401/14

    CPC分类号： A61K31/506 ,  C07D401/14 ,  Y10T428/13

    摘要： The present invention relates to a regimen for the administration of a pyrimidylaminobenzamide of formula I as defined herein for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by the Bcr-Abl oncoprotein, the cell transmembrane tyrosine kinase receptor c-Kit, DDR1 (discoidin domain receptor 1), DDR2 (discoidin domain receptor 2) or PDGF-R (platelet derived growth factor receptor) kinase activity.

    摘要翻译： 本发明涉及用于施用如本文定义的式I的嘧啶基氨基苯甲酰胺治疗增殖性疾病，特别是固体和液体肿瘤以及由Bcr-Abl癌蛋白，细胞跨膜酪氨酸激酶受体介导的其它病理状况的方案 c-Kit，DDR1（盘状结构域受体1），DDR2（盘状结构域受体2）或PDGF-R（血小板衍生生长因子受体）激酶活性。

    METHOD OF TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY BCR-ABL, C-KIT, DDR1, DDR2 OR PDGF-R KINASE ACTIVITY
    3.
    发明申请
    METHOD OF TREATING PROLIFERATIVE DISORDERS AND OTHER PATHOLOGICAL CONDITIONS MEDIATED BY BCR-ABL, C-KIT, DDR1, DDR2 OR PDGF-R KINASE ACTIVITY 审中-公开
    BCR-ABL，C-kit，DDR1，DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的治疗方法

    公开(公告)号：US20150313900A1

    公开(公告)日：2015-11-05

    申请号：US14797716

    申请日：2015-07-13

    申请人： Tomasz Szczudlo ,  Richard Woodman ,  Ophelia Yin

    发明人： Tomasz Szczudlo ,  Richard Woodman ,  Ophelia Yin

    IPC分类号： A61K31/506

    CPC分类号： A61K31/506 ,  C07D401/14 ,  Y10T428/13

    摘要： The present invention relates to a regimen for the administration of a pyrimidyl-aminobenzamide of formula I as defined herein for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by the Bcr-Abl oncoprotein, the cell transmembrane tyrosine kinese receptor c-Kit, DDR1 (discoidin domain receptor 1), DDR2 (discoidin domain receptor 2) or PDGF-R (platelet derived growth factor receptor) kinase activity.

    摘要翻译： 本发明涉及用于施用如本文定义的式I的嘧啶基 - 氨基苯甲酰胺治疗增殖性疾病，特别是固体和液体肿瘤以及由Bcr-Abl癌蛋白，细胞跨膜酪氨酸介导的其它病理状况的方案 kini受体c-Kit，DDR1（盘状结构域受体1），DDR2（盘状蛋白结构域受体2）或PDGF-R（血小板衍生生长因子受体）激酶活性。

    Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity
    5.
    发明授权
    Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity 有权
    治疗由Bcr-Abl，c-Kit，DDR1，DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的方法

    公开(公告)号：US09061029B2

    公开(公告)日：2015-06-23

    申请号：US13509626

    申请日：2010-11-17

    申请人： Neil Gallagher ,  Ophelia Yin

    发明人： Neil Gallagher ,  Ophelia Yin

    IPC分类号： A61K31/506 ,  C07D239/69 ,  A61K9/00

    CPC分类号： A61K31/506 ,  A61K9/0095 ,  C07D239/69

    摘要： The present invention relates to a regimen for the administration of a pyrimidylaminobenzamide of formula I wherein the radicals as defined herein, or of a pharmaceutically acceptable salt thereof, for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by the Bcr-Abl oncoprotein, the cell transmembrane tyrosine kinase receptor c-Kit, DDR1 (discoidin domain receptor 1), DDR2 (discoidin domain receptor 2) or PDGF-R (platelet derived growth factor receptor) kinase activity, wherein the pyrimidylaminobenzamide of formula I and, optionally, pharmaceutically acceptable carriers, are dispersed in a fruit preparation.

    摘要翻译： 本发明涉及用于施用式I嘧啶基氨基苯甲酰胺的方案，其中本文所定义的基团或其药学上可接受的盐用于治疗增殖性疾病，特别是固体和液体肿瘤，以及由其介导的其它病理学病症 Bcr-Abl癌蛋白，细胞跨膜酪氨酸激酶受体c-Kit，DDR1（盘状蛋白结构域受体1），DDR2（盘状蛋白结构域受体2）或PDGF-R（血小板衍生生长因子受体）激酶活性，其中式 I和任选的药学上可接受的载体分散在水果制剂中。