公开(公告)号：US20090125288A1

公开(公告)日：2009-05-14

申请号：US12085059

申请日：2006-11-24

申请人： Ian Main ,  Lun Li ,  Orestis Papasouliotis ,  Thomas Leonard

发明人： Ian Main ,  Lun Li ,  Orestis Papasouliotis ,  Thomas Leonard

IPC分类号： E21B43/00 ,  E21B49/00

CPC分类号： E21B49/00 ,  E21B43/00

摘要： A computer system for modelling and controlling a hydrocarbon reservoir through management of fluid flow at individual wells. The computer system has program instructions which operate a computer model which uses oilfield production data to provide a model of future production. The model comprises an optimal regression model which represents injector and producer wells whose fluid flow characteristics are highly correlated with the fluid flow characteristics of the well of interest; the application of parsimonious information criterion techniques to identify well pairs that statistically contribute information to the optimal regression model; and a statistical reservoir model comprising the product of the optimal regression model and a significance matrix. The system is also provided with control means, responsive to the output of the computer model in order to control wells in the hydrocarbon reservoir.

摘要翻译： 一种用于通过管理各个井的流体流动来建模和控制烃储层的计算机系统。 计算机系统具有操作计算机模型的程序指令，其使用油田生产数据来提供未来生产的模型。 该模型包括一个最佳回归模型，该模型表示其流体流动特性与感兴趣的井的流体流动特性高度相关的喷油器和生产井; 应用简约的信息标准技术来识别统计上将信息贡献给最优回归模型的良好对; 以及包含最优回归模型和显着矩阵的乘积的统计储层模型。 该系统还具有控制装置，响应于计算机模型的输出，以便控制油气藏中的井。

公开(公告)号：US08417496B2

公开(公告)日：2013-04-09

申请号：US12085059

申请日：2006-11-24

申请人： Ian Main ,  Lun Li ,  Orestis Papasouliotis ,  Thomas Leonard

发明人： Ian Main ,  Lun Li ,  Orestis Papasouliotis ,  Thomas Leonard

IPC分类号： G06F17/50 ,  G06F7/60 ,  G06F17/10 ,  G06F7/50 ,  G06G7/48

CPC分类号： E21B49/00 ,  E21B43/00

摘要： A computer system for modelling and controlling a hydrocarbon reservoir through management of fluid flow at individual wells. The computer system has program instructions which operate a computer model which uses oilfield production data to provide a model of future production. The model comprises an optimal regression model which represents injector and producer wells whose fluid flow characteristics are highly correlated with the fluid flow characteristics of the well of interest; the application of parsimonious information criterion techniques to identify well pairs that statistically contribute information to the optimal regression model; and a statistical reservoir model comprising the product of the optimal regression model and a significance matrix. The system is also provided with control means, responsive to the output of the computer model in order to control wells in the hydrocarbon reservoir.

摘要翻译： 一种用于通过管理各个井的流体流动来建模和控制烃储层的计算机系统。 计算机系统具有操作计算机模型的程序指令，其使用油田生产数据来提供未来生产的模型。 该模型包括一个最佳回归模型，该模型表示其流体流动特性与感兴趣的井的流体流动特性高度相关的喷油器和生产井; 应用简约的信息标准技术来识别统计上将信息贡献给最优回归模型的良好对; 以及包含最优回归模型和显着矩阵的乘积的统计储层模型。 该系统还具有控制装置，响应于计算机模型的输出，以便控制油气藏中的井。

公开(公告)号：US20090186040A1

公开(公告)日：2009-07-23

申请号：US12139078

申请日：2008-06-13

申请人： Sharon J. Busby ,  Jane A. Gross ,  Jennifer Visich ,  Ivan Nestorov ,  Alain Munafo ,  Orestis Papasouliotis ,  Claudia Pena Rossi

发明人： Sharon J. Busby ,  Jane A. Gross ,  Jennifer Visich ,  Ivan Nestorov ,  Alain Munafo ,  Orestis Papasouliotis ,  Claudia Pena Rossi

IPC分类号： A61K39/395 ,  A61P37/00

CPC分类号： A61K9/06 ,  A61K9/0019 ,  A61K38/177 ,  A61K45/06 ,  A61K47/6835 ,  A61K2300/00

摘要： In various embodiments, the present invention provides methods, compositions, dosing, and administration schedules for treatment of autoimmune diseases, including systemic erythematosus (SLE), for example, comprising administering to a patient in need of such treatment a TACI-Ig fusion molecule such as atacicept. In one embodiment, the TACI-Ig fusion molecule is administered in amount sufficient to slow, suppress or inhibit proliferation-inducing functions of BLyS and APRIL, in particular the use of multiple administrations of the fusion molecule at relatively low dose over the course of the treatment.

摘要翻译： 在各种实施方案中，本发明提供了治疗自身免疫疾病（包括系统性红斑狼疮（SLE））的方法，组合物，给药和给药方案，例如包括向需要这种治疗的患者施用TACI-Ig融合分子， 如atacicept。 在一个实施方案中，TACI-Ig融合分子以足以减缓，抑制或抑制BLyS和APRIL的增殖诱导功能的量施用，特别是在该过程中以相对低的剂量使用多次施用融合分子 治疗。