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公开(公告)号：US20230241099A1
公开(公告)日：2023-08-03
申请号：US18116417
申请日：2023-03-02
发明人： Ravi Krishnan , Paul Rennie
IPC分类号： A61K31/737 , A61P19/08 , A61K9/00
CPC分类号： A61K31/737 , A61P19/08 , A61K9/0019
摘要： The present invention relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of disease or disorders associated with bone marrow pathologies in the musculoskeletal system of a mammal. In particular, the invention relates to use of polysulfated polysaccharides, such as pentosan polysulfate, in treatment of bone marrow edema lesions or spinal Modic Endplate Changes as assessed by magnetic resonance imaging (MRI).
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公开(公告)号：US20200246374A1
公开(公告)日：2020-08-06
申请号：US16636545
申请日：2018-08-06
发明人： Ravi Krishnan , Paul Rennie
IPC分类号： A61K31/737 , A61K9/00 , A61P19/08
摘要： The present invention relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of disease or disorders associated with bone marrow pathologies in the musculoskeletal system of a mammal. In particular, the invention relates to use of polysulfated polysaccharides, such as pentosan polysulfate, in treatment of bone marrow edema lesions or spinal Modic Endplate Changes as assessed by magnetic resonance imaging (MRI).
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公开(公告)号：US20230381219A1
公开(公告)日：2023-11-30
申请号：US18204492
申请日：2023-06-01
发明人： Paul Rennie , Ravi Krishnan
IPC分类号： A61K31/737
CPC分类号： A61K31/737 , A61K9/0019
摘要： The present invention relates to medical use of polysulfated polysaccharides and compositions thereof in the treatment of post-operative joint pain in a mammal. In particular, the invention relates to the use of polysulfated polysaccharides and compositions thereof in the treatment of aseptic persistent pain after joint arthroplasty in a mammal.
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公开(公告)号：US20210330695A1
公开(公告)日：2021-10-28
申请号：US17284071
申请日：2019-10-10
发明人： Paul Rennie , Ravi Krishnan
IPC分类号： A61K31/737 , A61K31/727 , A61K31/7032 , A61P25/04 , A61P19/02
摘要： The present disclosure relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions. In particular, the disclosure relates to use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions mediated by mature Nerve Growth Factor (NGF) or its precursor pro-Nerve Growth Factor (pro-NGF).
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公开(公告)号：US11752169B2
公开(公告)日：2023-09-12
申请号：US17284071
申请日：2019-10-10
发明人： Paul Rennie , Ravi Krishnan
IPC分类号： A61K31/737 , A61P19/02 , A61P25/04 , A61K31/7032 , A61K31/727
CPC分类号： A61K31/737 , A61K31/7032 , A61K31/727 , A61P19/02 , A61P25/04
摘要： The present disclosure relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions. In particular, the disclosure relates to use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions mediated by mature Nerve Growth Factor (NGF) or its precursor pro-Nerve Growth Factor (pro-NGF).
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公开(公告)号：US20210000862A1
公开(公告)日：2021-01-07
申请号：US16976671
申请日：2019-02-27
发明人： Paul Rennie , Ravi Krishnan
IPC分类号： A61K31/737
摘要： The present invention relates to medical use of polysulfated polysaccharides and compositions thereof in the treatment of post-operative joint pain in a mammal. In particular, the invention relates to the use of the polysulfated polysaccharide, pentosan polysulfate, and compositions thereof in the treatment of aseptic persistent pain after joint arthroplasty in a mammal.
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公开(公告)号：US11701382B2
公开(公告)日：2023-07-18
申请号：US16976671
申请日：2019-02-27
发明人： Paul Rennie , Ravi Krishnan
IPC分类号： A61K31/737 , A61K9/00
CPC分类号： A61K31/737 , A61K9/0019
摘要： The present invention relates to medical use of polysulfated polysaccharides and compositions thereof in the treatment of post-operative joint pain in a mammal. In particular, the invention relates to the use of the polysulfated polysaccharide, pentosan polysulfate, and compositions thereof in the treatment of aseptic persistent pain after joint arthroplasty in a mammal.
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公开(公告)号：US20240066050A1
公开(公告)日：2024-02-29
申请号：US18224492
申请日：2023-07-20
发明人： Paul Rennie , Ravi Krishnan
IPC分类号： A61K31/737 , A61K31/7032 , A61K31/727 , A61P19/02 , A61P25/04
CPC分类号： A61K31/737 , A61K31/7032 , A61K31/727 , A61P19/02 , A61P25/04
摘要： The present disclosure relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions. In particular, the disclosure relates to use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions mediated by mature Nerve Growth Factor (NGF) or its precursor pro-Nerve Growth Factor (pro-NGF).
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公开(公告)号：US20230136817A1
公开(公告)日：2023-05-04
申请号：US17917904
申请日：2021-04-09
发明人： Paul Rennie , Ravi KRISHNAN
IPC分类号： A61K31/737 , A61P11/00 , A61P31/14
摘要： Methods for the treatment of Acute Respiratory Distress Syndrome (ARDS), particularly ARDS caused by viral infections such as influenza and SARS-CoV-2, comprising the administration of pentosan polysulfate (PPS) are provided. Some provided methods comprise the administration of sodium pentosan polysulfate. Prophylactic methods comprising the administration (for example, intra-nasally) of sodium pentosan polysulfate to inactivate a vims which is causative of ARDS are also provided.
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公开(公告)号：US11617763B2
公开(公告)日：2023-04-04
申请号：US16636545
申请日：2018-08-06
发明人： Ravi Krishnan , Paul Rennie
IPC分类号： A61K31/737 , A61P19/08 , A61K9/00
摘要： The present invention relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of disease or disorders associated with bone marrow pathologies in the musculoskeletal system of a mammal. In particular, the invention relates to use of polysulfated polysaccharides, such as pentosan polysulfate, in treatment of bone marrow edema lesions or spinal Modic Endplate Changes as assessed by magnetic resonance imaging (MRI).
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