公开(公告)号：US20070123571A1

公开(公告)日：2007-05-31

申请号：US10557196

申请日：2004-06-01

申请人： Palaniswamy Raj ,  Adrain Shephard ,  Huw Jones

发明人： Palaniswamy Raj ,  Adrain Shephard ,  Huw Jones

IPC分类号： A61K31/4439

CPC分类号： A61K31/44 ,  A61K45/06 ,  A61K2300/00

摘要： There is disclosed the use of triprolidine, in combination with at least one further active pharmaceutical agent, for enabling an individual to wake refreshed after sleep and the method of treating such an individual with triprolidine. Use of triprolidine, in combination with at least one further active pharmaceutical agent, as active ingredient in the manufacture of a composition for the treatment of sleep disorders is also described. A method of treating sleep of a person suffering from a sleep disorder, which method comprises administration of an effective dose of triprolidine, in combination with at least one further active pharmaceutical agent, as active i ingredient to such a person is also described. The triprolidine is administered shortly before a person wishes to fall asleep, preferably orally and most commonly in the form of a tablet containing up to 20 mg, e.g. 0.1 mg, 1.25 mg or 2.5 mg, of the active ingredient. The triprolidine is also effective in enabling an individual to sleep more easily.

摘要翻译： 公开了使用与至少一种其它活性药剂组合的三洛定，以使个体在睡眠后醒来醒来，以及使用三氯哌啶来治疗这种个体的方法。 还描述了在制备用于治疗睡眠障碍的组合物中使用三洛定与至少一种其它活性药剂组合作为活性成分。 还描述了一种治疗患有睡眠障碍的人的睡眠的方法，该方法包括与至少一种其它活性药剂组合施用有效剂量的三洛定作为这种人的活性成分。 三吡咯烷在人想要入睡之前不久就被施用，优选口服，最通常是含有至多20mg的片剂形式，例如， 0.1mg，1.25mg或2.5mg的活性成分。 三吡咯也有助于使个体更容易睡觉。