公开(公告)号：US20200277352A1

公开(公告)日：2020-09-03

申请号：US16651242

申请日：2018-09-17

申请人： Drew C. Deniger ,  Steven A. Rosenberg ,  Anna Pasetto ,  Rami Yoseph ,  Winifred M. Lo ,  Yong-Chen Lu ,  Maria R. Parkhurst ,  Paul F. Robbins ,  Parisa Malekzadeh

发明人： Drew C. Deniger ,  Steven A. Rosenberg ,  Anna Pasetto ,  Rami Yoseph ,  Winifred M. Lo ,  Yong-Chen Lu ,  Maria R. Parkhurst ,  Paul F. Robbins ,  Parisa Malekzadeh

IPC分类号： C07K14/725 ,  G01N33/574 ,  A61K35/17 ,  C12N5/0783

摘要： Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.