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    Substituted 1-alkylcinnolin-4(1H)-one derivatives, preparation thereof and therapeutic application of same
    2.
    发明授权
    Substituted 1-alkylcinnolin-4(1H)-one derivatives, preparation thereof and therapeutic application of same 有权
    取代的1-烷基噌啉-4（1H） - 酮衍生物，其制备方法及其治疗应用

    公开(公告)号：US08420651B2

    公开(公告)日：2013-04-16

    申请号：US13262869

    申请日：2010-04-06

    Applicant: Elodie Barbagallo ,  Carole Legeay ,  Murielle Rinaldi-Carmona ,  Pascale Roux ,  Claude Vernhet

    Inventor： Elodie Barbagallo ,  Carole Legeay ,  Murielle Rinaldi-Carmona ,  Pascale Roux ,  Claude Vernhet

    IPC: A61K31/50 ,  A61K31/501

    CPC classification number: C07D237/28

    Abstract: The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C2-C5)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; R1 represents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; R2 represents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from —S-Alk, —SO-Alk, —SO2-Alk, —CO—N(R4)-Alk, —N(R4)SO2-Alk, —N(R4)CO-Alk, —N(R4)SO2—N(Alk)2; R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; R4 represents a hydrogen atom or a (C1-C4)alkyl; Alk represents an unsubstituted or substituted (C1-C4)alkyl. Preparation process and therapeutic application.

    Abstract translation: 本发明的主题是对应于式（I）的化合物，其中：X表示未被取代或被Alk基取代一次或多次的二价（C 2 -C 5）亚烷基; R 1表示苯基，萘基，吡啶基，1-苯并噻吩基或1,3-苯并二恶唑基; R 2表示氢原子，卤素原子，Alk基团，OAlk基团或选自-S-Alk，-SO-Alk，-SO 2 -Alk，-CO-N（R 4）-Alk，-N （R4）SO2-Alk，-N（R4）CO-Alk，-N（R4）SO2-N（Alk）2; R 3表示氢原子，卤素原子，Alk基团或OAlk基团; R4表示氢原子或（C1-C4）烷基; Alk表示未取代或取代的（C1-C4）烷基。 制备工艺及治疗应用。

    SUBSTITUTED 1-ALKYLCINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION OF SAME
    3.
    发明申请
    SUBSTITUTED 1-ALKYLCINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION OF SAME 有权
    取代的1-烷基喹啉-4-（1H） - 酮衍生物，其制备方法及其相应的应用

    公开(公告)号：US20120129864A1

    公开(公告)日：2012-05-24

    申请号：US13262869

    申请日：2010-04-06

    Applicant: Elodie Barbagallo ,  Carole Legeay ,  Murielle Rinaldi-Carmona ,  Pascale Roux ,  Claude Vernhet

    Inventor： Elodie Barbagallo ,  Carole Legeay ,  Murielle Rinaldi-Carmona ,  Pascale Roux ,  Claude Vernhet

    IPC: A61K31/502 ,  C07D401/04 ,  A61P3/04 ,  A61P3/10 ,  A61P37/08 ,  A61P25/00 ,  A61P9/00 ,  A61P1/00 ,  A61P35/00 ,  C07D237/28 ,  A61P29/00

    CPC classification number: C07D237/28

    Abstract: The subject of the present invention is compounds corresponding to the formula (I) in which: X represents a divalent (C2-C5)alkylene radical which is unsubstituted or substituted one or more times by an Alk group; R1 represents a phenyl, a naphthyl, a pyridyl, a 1-benzothienyl or a 1,3-benzodioxolyl; R2 represents a hydrogen atom, a halogen atom, an Alk group, an OAlk group or else a group chosen from —S-Alk, —SO-Alk, —SO2-Alk, —CO—N(R4)-Alk, —N(R4)SO2-Alk, —N(R4)CO-Alk, —N(R4)SO2—N(Alk)2; R3 represents a hydrogen atom, a halogen atom, an Alk group or an OAlk group; R4 represents a hydrogen atom or a (C1-C4)alkyl; Alk represents an unsubstituted or substituted (C1-C4)alkyl. Preparation process and therapeutic application.

    Abstract translation: 本发明的主题是对应于式（I）的化合物，其中：X表示未被取代或被Alk基取代一次或多次的二价（C 2 -C 5）亚烷基; R 1表示苯基，萘基，吡啶基，1-苯并噻吩基或1,3-苯并二恶唑基; R 2表示氢原子，卤素原子，Alk基团，OAlk基团或选自-S-Alk，-SO-Alk，-SO 2 -Alk，-CO-N（R 4）-Alk，-N （R4）SO2-Alk，-N（R4）CO-Alk，-N（R4）SO2-N（Alk）2; R 3表示氢原子，卤素原子，Alk基团或OAlk基团; R4表示氢原子或（C1-C4）烷基; Alk表示未取代或取代的（C1-C4）烷基。 制备工艺及治疗应用。

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