公开(公告)号：US08565885B2

公开(公告)日：2013-10-22

申请号：US12865292

申请日：2009-01-30

申请人： Jiande Chen ,  Pasricha Pankaj Jay

发明人： Jiande Chen ,  Pasricha Pankaj Jay

IPC分类号： A61N1/05

CPC分类号： A61N1/36007

摘要： The disclosure is a method of treatment for obesity, in an individual in need thereof comprising positioning stimulatory electrodes in the distal small intestines or ileum, and administering electrical stimulation in trains of pulses or repetitive pulses, where the electrical stimulation is effective, at least in part in, stimulating the vagal afferent and efferent activity, of the distal small intestines or ileum, in the individual. The stimulation of the vagal afferent and efferent activity leads to the regulation of the ileal brake. Specifically, the electrical stimulation is provided in trains of pulses. Also, described is a method of treatment for functional gastrointestinal disease by ileal electrical stimulation. Further this invention provides a method of treatment for an eating disorder comprising administering ileal electrical stimulation effective, at least in part, in stimulating the vagal and sympathetic pathways. The stimulatory electrodes are placed by laparoscopic, endoscopic or surgical means.

摘要翻译： 本公开是在需要的个体中治疗肥胖症的方法，包括将远端小肠或回肠中的刺激电极定位，并且在电刺激有效的脉冲或重复脉冲列中给予电刺激，至少在 部分地，刺激远端小肠或回肠的迷走神经传入和传出活动。 迷走神经传入和传出活动的刺激导致回肠制动器的调节。 具体地说，在脉冲串中提供电刺激。 此外，描述了通过回肠电刺激治疗功能性胃肠道疾病的方法。 此外，本发明提供了一种饮食障碍的治疗方法，包括给予至少部分刺激迷走神经和交感神经通路有效的回肠电刺激。 刺激电极通过腹腔镜，内窥镜或外科手段放置。