公开(公告)号：US20110091473A1

公开(公告)日：2011-04-21

申请号：US12739270

申请日：2008-10-22

Applicant: Jakub Golab ,  Magdalena Winiarska ,  Paul Parren ,  Wendy Mackus ,  Patrick Engelberts

Inventor： Jakub Golab ,  Magdalena Winiarska ,  Paul Parren ,  Wendy Mackus ,  Patrick Engelberts

IPC: A61K39/395 ,  A61P37/02 ,  A61P9/10

CPC classification number: C07K16/2887 ,  A61K39/39558 ,  A61K45/06 ,  C07K2317/732 ,  C07K2317/734 ,  A61K2300/00

Abstract: Antibody capable of mediating effector function which specifically binds to a multiple membrane spanning antigen or to an antigen which forms dimers or multimers (i) for use in combination with a cholesterol-increasing agent in the treatment of a disease or disorder associated with said antigen, wherein antibody-induced effector function has a beneficial effect on said disease or disorder or (ii) for use in the treatment of such disease or disorder, wherein the antibody is to be administered to a subject undergoing therapy with a cholesterol-lowering agent, such as a statin, and wherein the subject is withdrawn from treatment with the cholesterol-lowering agent prior to the administration of the antibody. Furthermore, a kit of parts comprising such antibody as well as a cholesterol-increasing agent.

Abstract translation: 能够介导效应子功能的抗体，其特异性结合跨越抗原的多重膜或形成二聚体或多聚体的抗原（i）与胆固醇增加剂组合用于治疗与所述抗原相关的疾病或病症， 其中抗体诱导的效应子功能对所述疾病或病症具有有益效果，或（ii）用于治疗这种疾病或病症，其中抗体将被施用于正在用降胆固醇药物治疗的受试者，例如 作为他汀类，并且其中所述受试者在施用所述抗体之前从所述胆固醇降低剂中撤出治疗。 此外，还包含一些包含这种抗体的部分试剂盒以及一种胆固醇增加剂。