公开(公告)号：US06620594B1

公开(公告)日：2003-09-16

申请号：US09423410

申请日：1999-11-04

申请人： Jean-Paul Giacobino ,  Patrick Muzzin ,  Olivier Boss

发明人： Jean-Paul Giacobino ,  Patrick Muzzin ,  Olivier Boss

IPC分类号： C12P2106

CPC分类号： C07K14/705 ,  A61K48/00 ,  C12N2799/021 ,  C12N2799/022 ,  C12N2799/028

摘要： The present invention relates to the cloned genes which code for uncoupling proteins controlling thermogenesis in human skeletal muscle and heart. A further aspect of the present invention relates to the use of the said genes for correcting dysfunctions of thermogenesis in human skeletal muscle and heart. The present invention makes it possible to exploit novel therapeutic (or preventive) methods for disorders such as obesity or cachexia. As a result of the identification and isolation of the genes coding for UCP3L and UCP3S, it is, in effect, possible to develop medicaments which act on the basis of a correction, by gene therapy or by antisense oligonucleotides relating to the sequence of the gene in question or to one of its fragments, of a lack or an excess of UCP3.

摘要翻译： 本发明涉及编码解偶联蛋白质的克隆基因，其控制人骨骼肌和心脏中的产热。 本发明的另一方面涉及所述基因用于校正人骨骼肌和心脏中发热功能的功能。本发明使得可以利用新的治疗（或预防）方法用于诸如肥胖或恶病质的疾病。 作为鉴定和分离编码UCP3L和UCP3S的基因的结果，实际上可能开发基于校正，基因治疗或与基因序列相关的反义寡核苷酸起作用的药物 或其中一个片段，缺乏或过量的UCP3。