公开(公告)号：US20070232647A1

公开(公告)日：2007-10-04

申请号：US11597679

申请日：2005-05-13

申请人： Leopold Goetze ,  Marcus Kehrli ,  Anthony Ricketts ,  Patrick Taube

发明人： Leopold Goetze ,  Marcus Kehrli ,  Anthony Ricketts ,  Patrick Taube

IPC分类号： A61K31/4709 ,  A23K1/16 ,  A23K1/18 ,  A61K31/19 ,  A61K31/192 ,  A61P1/00 ,  A61P15/00 ,  A61P37/00 ,  A61P3/00 ,  A61P1/16 ,  A61K31/422 ,  A61K31/427 ,  A61K31/451 ,  A61K31/47

CPC分类号： A61K31/4709 ,  A23K20/111 ,  A23K50/10 ,  A61K31/19 ,  A61K31/192 ,  A61K31/422 ,  A61K31/427 ,  A61K31/451 ,  A61K31/47

摘要： The use of a PPAR agonist in the manufacture of a medicament to increase ruminant serum glucose concentrations, and preferably, the use for the palliative, prophylactic or curative treatment of ruminant disease associated with reduced serum glucose concentration. The ruminant disease associated with reduced serum glucose concentration includes fatty liver syndrome, dystocia, immune dysfunction, impaired immune function, toxification, primary ketosis, secondary ketosis, downer cow syndrome, indigestion, inappetence, retained placenta, displaced abomasum, mastitis, (endo-)-metritis, infertility, low fertility, lameness, subacute rumen acidosis and inadequate nutrient intake associated with stress e.g. heat, poor housing, overcrowding, shipping, dominance or illness, and to increase milk quality and yield.

摘要翻译： PPAR激动剂在制备增加反刍动物血清葡萄糖浓度的药物中的用途，优选用于与降低的血清葡萄糖浓度相关的反刍动物疾病的姑息治疗，预防或治疗性治疗。 与血清葡萄糖浓度降低相关的反刍动物疾病包括脂肪肝综合征，难产，免疫功能障碍，免疫功能受损，毒素化，原发酮症，继发性酮症，下尿综合征，消化不良，食欲不振，留置胎盘，置换性皱胃，乳腺炎， ） - 不孕不育，低生育率，跛行，亚急性瘤胃酸中毒和与应激相关的营养摄入量不足例如 热，住房不足，拥挤，运输，优势或疾病，并提高牛奶质量和产量。