公开(公告)号：US08535716B2

公开(公告)日：2013-09-17

申请号：US11097487

申请日：2005-04-01

申请人： John Hilfinger ,  Jae Seung Kim ,  Paul Kijek

发明人： John Hilfinger ,  Jae Seung Kim ,  Paul Kijek

IPC分类号： A61K9/22

CPC分类号： A61K9/2013 ,  A61K9/2081 ,  A61K9/2846 ,  A61K9/5015 ,  A61K9/5057 ,  A61K31/225

摘要： A pharmaceutical composition is provided that includes an active ingredient in the form of a powder or granule, a water soluble high molecular weight excipient and a water insoluble hydrophilic amphiphilic excipient. These ingredients are solution mixed and dried to form a modified pharmaceutical ingredient in simultaneous contact with both the water soluble high molecular weight excipient and the water insoluble hydrophilic amphiphilic excipient. Adjuvants are compacted about the modified pharmaceutical ingredient as well as a release control agent. The release control agent being present at levels from 1 to 40 total weight percent of the pharmaceutical composition.

摘要翻译： 提供了药物组合物，其包含粉末或颗粒形式的活性成分，水溶性高分子量赋形剂和水不溶性亲水两亲性赋形剂。 这些成分是溶液混合并干燥以形成与水溶性高分子量赋形剂和水不溶性亲水性亲水性赋形剂同时接触的改性药物成分。 佐剂关于改性药物成分以及释放控制剂压实。 释放控制剂以药物组合物的总重量的1至40的水平存在。

公开(公告)号：US20050220876A1

公开(公告)日：2005-10-06

申请号：US11097487

申请日：2005-04-01

申请人： John Hilfinger ,  Jae Kim ,  Paul Kijek

发明人： John Hilfinger ,  Jae Kim ,  Paul Kijek

IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/50 ,  A61K31/225 ,  A61K38/12

CPC分类号： A61K9/2013 ,  A61K9/2081 ,  A61K9/2846 ,  A61K9/5015 ,  A61K9/5057 ,  A61K31/225

摘要： A pharmaceutical composition is provided that includes an active ingredient in the form of a powder or granule, a water soluble high molecular weight excipient and a water insoluble hydrophilic amphiphilic excipient. These ingredients are solution mixed and dried to form a modified pharmaceutical ingredient in simultaneous contact with both the water soluble high molecular weight excipient and the water insoluble hydrophilic amphiphilic excipient. Adjuvants are compacted about the modified pharmaceutical ingredient as well as a release control agent. The release control agent being present at levels from 1 to 40 total weight percent of the pharmaceutical composition.

摘要翻译： 提供了药物组合物，其包含粉末或颗粒形式的活性成分，水溶性高分子量赋形剂和水不溶性亲水两亲性赋形剂。 这些成分是溶液混合并干燥以形成与水溶性高分子量赋形剂和水不溶性亲水性亲水性赋形剂同时接触的改性药物成分。 佐剂关于改性药物成分以及释放控制剂压实。 释放控制剂以药物组合物的总重量的1至40的水平存在。