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公开(公告)号：US07723313B2
公开(公告)日：2010-05-25
申请号：US11494363
申请日：2006-07-26
Applicant: Noel P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
Inventor： Noel P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
CPC classification number: G01N33/6881 , A61K38/57 , A61K48/00 , G01N33/57484
Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
Abstract translation: 本发明提供了通过向与组织相关的细胞提供外源PEDF来抑制组织内的血管生成的方法。 外源PEDF的存在抑制组织内的血管发生，部分原因是干扰血管内皮在组织内扩张的能力。 本发明还提供了确定肿瘤严重性的方法，该方法是测定肿瘤内PEDF的存在。 为了促进本发明的方法，本发明提供包含PEDF来源的药物组合物。
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公开(公告)号：US06919309B2
公开(公告)日：2005-07-19
申请号：US10342243
申请日：2003-01-14
Applicant: Noël P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
Inventor： Noël P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
CPC classification number: C07K14/811 , A61K38/57 , A61K48/00 , G01N33/57484 , G01N33/6881
Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
Abstract translation: 本发明提供了通过向与组织相关的细胞提供外源PEDF来抑制组织内的血管生成的方法。 外源PEDF的存在抑制组织内的血管发生，部分原因是干扰血管内皮在组织内扩张的能力。 本发明还提供了通过测定肿瘤内PEDF的存在来确定肿瘤严重程度的方法。 本发明还提供抑制内皮细胞迁移的方法，刺激哺乳动物毛发生长的方法，抑制肿瘤生长的方法，诱导成神经细胞瘤细胞分化的方法，减慢生长的方法 的神经母细胞瘤细胞，以及治疗哺乳动物缺血性视网膜病变的方法。 为了促进本发明的方法，本发明提供包含PEDF来源的药物组合物。
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Patent Agency Ranking
公开(公告)号：US06797691B1
公开(公告)日：2004-09-28
申请号：US09603478
申请日：2000-06-23
Applicant: Noël P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
Inventor： Noël P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
IPC: A61K3816
CPC classification number: C07K14/811 , A61K38/57 , A61K48/00 , G01N33/57484 , G01N33/6881
Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor by assaying for the presence of PEDF within the tumor. The invention further provides a method of inhibiting endothelial cell migration, a method of stimulating the growth of hair in a mammal, a method for inhibiting the growth of a tumor, a method of inducing differentiation of a neuroblastoma cell, a method of slowing the growth of a neuroblastoma cell, and method of treating ischemic retinopathy in a mammal. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
Abstract translation: 本发明提供了通过向与组织相关的细胞提供外源PEDF来抑制组织内的血管生成的方法。 外源PEDF的存在抑制组织内的血管发生，部分原因是干扰血管内皮在组织内扩张的能力。 本发明还提供了通过测定肿瘤内PEDF的存在来确定肿瘤严重程度的方法。 本发明还提供抑制内皮细胞迁移的方法，刺激哺乳动物毛发生长的方法，抑制肿瘤生长的方法，诱导成神经细胞瘤细胞分化的方法，减慢生长的方法 的神经母细胞瘤细胞，以及治疗哺乳动物缺血性视网膜病变的方法。 为了促进本发明的方法，本发明提供了包含PEDF来源的药物组合物。
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公开(公告)号：US06288024B1
公开(公告)日：2001-09-11
申请号：US09122079
申请日：1998-07-23
Applicant: Noel P. Bouck , David W. Dawson , Paul R. Gillis
Inventor： Noel P. Bouck , David W. Dawson , Paul R. Gillis
IPC: A61K3816
CPC classification number: A61K38/57 , C07K14/811
Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
Abstract translation: 本发明提供了通过向与组织相关的细胞提供外源性SLED来抑制组织内的血管发生的方法。 外源性SLED的存在抑制组织内的血管发生，部分原因是干扰血管内皮在组织内扩张的能力。 本发明还提供了一种用于确定肿瘤严重性的方法，该方法是测定肿瘤内SLED的存在。 为了促进本发明的方法，本发明提供了包含SLED来源的药物组合物。
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公开(公告)号：US07105496B2
公开(公告)日：2006-09-12
申请号：US10603387
申请日：2003-06-25
Applicant: Noël P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
Inventor： Noël P. Bouck , David W. Dawson , Paul R. Gillis , Olga Volpert , Susan E. Crawford , Veronica M. Stellmach
CPC classification number: G01N33/6881 , A61K38/57 , A61K48/00 , G01N33/57484
Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous PEDF to cells associated with the tissue. The presence of exogenous PEDF inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of PEDF within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of PEDF.
Abstract translation: 本发明提供了通过向与组织相关的细胞提供外源PEDF来抑制组织内的血管生成的方法。 外源PEDF的存在抑制组织内的血管发生，部分原因是干扰血管内皮在组织内扩张的能力。 本发明还提供了确定肿瘤严重性的方法，该方法是测定肿瘤内PEDF的存在。 为了促进本发明的方法，本发明提供包含PEDF来源的药物组合物。
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公开(公告)号：US06670333B2
公开(公告)日：2003-12-30
申请号：US09875114
申请日：2001-06-06
Applicant: Noel P. Bouck , David W. Dawson , Paul R. Gillis
Inventor： Noel P. Bouck , David W. Dawson , Paul R. Gillis
IPC: A61K31711
CPC classification number: A61K38/57 , C07K14/811
Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
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公开(公告)号：US06391850B2
公开(公告)日：2002-05-21
申请号：US09875223
申请日：2001-06-06
Applicant: Noel P. Bouck , David W. Dawson , Paul R. Gillis
Inventor： Noel P. Bouck , David W. Dawson , Paul R. Gillis
IPC: A61K3816
CPC classification number: A61K38/57 , C07K14/811
Abstract: The present invention provides a method of inhibiting angiogenesis within a tissue by providing exogenous SLED to cells associated with the tissue. The presence of exogenous SLED inhibits angiogenesis within the tissue, in part by interfering with the ability of vascular endothelia to expand within the tissue. The invention also provides a method for determining the severity of a tumor be assaying for the presence of SLED within the tumor. To facilitate the inventive methods, the present invention provides pharmaceutical compositions including sources of SLED.
Abstract translation: 本发明提供了通过向与组织相关的细胞提供外源性SLED来抑制组织内的血管发生的方法。 外源性SLED的存在抑制组织内的血管发生，部分原因是干扰血管内皮在组织内扩张的能力。 本发明还提供了一种用于确定肿瘤严重性的方法，该方法是测定肿瘤内SLED的存在。 为了促进本发明的方法，本发明提供了包含SLED来源的药物组合物。
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