公开(公告)号：US08745599B2

公开(公告)日：2014-06-03

申请号：US13354291

申请日：2012-01-19

申请人： Jenq Kuen Lee ,  Ming Yu Hung ,  Yuan Shin Hwang ,  Peng Sheng Chen

发明人： Jenq Kuen Lee ,  Ming Yu Hung ,  Yuan Shin Hwang ,  Peng Sheng Chen

IPC分类号： G06F9/45

CPC分类号： G06F8/434

摘要： A computer-implemented probabilistic pointer analysis method using SSA form comprises the steps of: evaluating a program in an SSA form comprising a target pointer to determine pointer relations between the target pointer, a plurality of aliased pointers related to the target pointer and at least a probable location of the target pointer; and generating a direct probabilistic relation between the target pointer and the at least a probable location of the target pointer according to the pointer relation.

摘要翻译： 使用SSA形式的计算机实现的概率指针分析方法包括以下步骤：评估包括目标指针的SSA形式的程序，以确定目标指针之间的指针关系，与目标指针相关的多个别名指针和至少一个 目标指针的可能位置; 以及根据所述指针关系，生成所述目标指针与所述目标指针的所述至少可能位置之间的直接概率关系。

公开(公告)号：US20130184775A1

公开(公告)日：2013-07-18

申请号：US13876999

申请日：2011-09-16

申请人： Peng-Sheng Chen ,  Shien-Fong Lin ,  Lan S. Chen

发明人： Peng-Sheng Chen ,  Shien-Fong Lin ,  Lan S. Chen

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/36053 ,  A61N1/36135 ,  A61N1/3615

摘要： A method of nerve stimulation produces therapeutic effects in an organ not directly innervated by the electrically stimulated nerve. The method includes identifying an electrical stimulation reaction threshold of at least one organ directly innervated by a parasympathetic nerve of a subject, identifying a reaction threshold of at least one tissue that is not directly innervated by the parasympathetic nerve of the subject after the parasympathetic nerve is electrically stimulated, and electrically stimulating the parasympathetic nerve with an electrical stimulation signal that is below the identified reaction threshold for the at least one directly innervated organ, but above a reaction threshold for the at least one tissue or organ that is not directly innervated by the parasympathetic nerve of the subject.

摘要翻译： 神经刺激的方法在不被电刺激的神经直接支配的器官中产生治疗效果。 所述方法包括鉴定由受试者的副交感神经直接支配的至少一个器官的电刺激反应阈值，鉴定在副交感神经之后不被受试者的副交感神经直接支配的至少一种组织的反应阈值 电刺激和电刺激副交感神经，其电刺激信号低于所述至少一个直接受神经支配的器官的鉴定反应阈值，但高于至少一个组织或器官的反应阈值，所述组织或器官不直接由 副交感神经的主题。

公开(公告)号：US20070123945A1

公开(公告)日：2007-05-31

申请号：US11606636

申请日：2006-11-29

申请人： Peng-Sheng Chen

发明人： Peng-Sheng Chen

IPC分类号： A61N1/00

CPC分类号： G01N33/6893 ,  A61N1/362 ,  G01N2333/48 ,  G01N2800/32

摘要： Methods and kits are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart. The methods and kits comprise measuring serum NGF levels in a subject and detecting increases in NGF levels over baseline. The methods may further comprise initiating preventive therapy in response to a detected increase in serum NGF levels.

摘要翻译： 提供了方法和试剂盒，用于确定心律不齐，心肌缺血，充血性心力衰竭和心脏其他患病状况发生的可能性增加。 方法和试剂盒包括测量受试者的血清NGF水平，并检测NGF水平超过基线的增加。 所述方法还可以包括响应于检测到的血清NGF水平的增加而启动预防性治疗。

公开(公告)号：US08660736B2

公开(公告)日：2014-02-25

申请号：US13568526

申请日：2012-08-07

申请人： Tien-Chen Chen ,  Kai-Sheng Lee ,  Peng-Sheng Chen

发明人： Tien-Chen Chen ,  Kai-Sheng Lee ,  Peng-Sheng Chen

IPC分类号： G05D1/00

CPC分类号： G05D1/0225 ,  G05D2201/0215

摘要： A method of navigating an autonomous mobile device to a base station is provided. In the method, when a detector detects a navigating signal sent out by the base station, the mobile device rotates in a first direction until the detector fails to detect the navigating signal, and a first time point is set at this time. Then, the mobile device rotates in a second direction opposite to the first direction until the detector fails to detect the navigating signal, and a second time point is set at this time. Afterward, the mobile device rotates in the first direction by a time computed based on the first and second time points to make the detector face the base station, and then, moves toward a direction pointed by the detector.

摘要翻译： 提供了一种将自主移动设备导航到基站的方法。 在该方法中，当检测器检测到由基站发出的导航信号时，移动设备沿第一方向旋转，直到检测器不能检测到导航信号，并且此时设置了第一时间点。 然后，移动装置沿着与第一方向相反的第二方向旋转，直到检测器未能检测到导航信号，此时设定第二时间点。 之后，移动设备在第一方向上旋转基于第一和第二时间点计算的时间，以使检测器面向基站，然后朝向检测器指向的方向移动。

公开(公告)号：US20130191818A1

公开(公告)日：2013-07-25

申请号：US13354291

申请日：2012-01-19

申请人： JENQ KUEN LEE ,  MING YU HUNG ,  YUAN SHIN HWANG ,  PENG SHENG CHEN

发明人： JENQ KUEN LEE ,  MING YU HUNG ,  YUAN SHIN HWANG ,  PENG SHENG CHEN

IPC分类号： G06F9/45

CPC分类号： G06F8/434

摘要： A computer-implemented probabilistic pointer analysis method using SSA form comprises the steps of: evaluating a program in an SSA form comprising a target pointer to determine pointer relations between the target pointer, a plurality of aliased pointers related to the target pointer and at least a probable location of the target pointer; and generating a direct probabilistic relation between the target pointer and the at least a probable location of the target pointer according to the pointer relation.

摘要翻译： 使用SSA形式的计算机实现的概率指针分析方法包括以下步骤：评估包括目标指针的SSA形式的程序，以确定目标指针之间的指针关系，与目标指针相关的多个别名指针和至少一个 目标指针的可能位置; 以及根据所述指针关系，生成所述目标指针与所述目标指针的所述至少可能位置之间的直接概率关系。

公开(公告)号：US20110218415A1

公开(公告)日：2011-09-08

申请号：US13127617

申请日：2009-10-28

申请人： Peng-Sheng Chen ,  Shien-Fong Lin

发明人： Peng-Sheng Chen ,  Shien-Fong Lin

IPC分类号： A61M5/00 ,  A61N1/365 ,  A61N1/39 ,  A61B5/04

CPC分类号： A61B5/04001 ,  A61B5/6846 ,  A61N1/3624 ,  A61N1/395

摘要： A method has been developed that detects cardiac arrhythmia from intrinsic cardiac nerve signals obtained from a heart in a patient. The method includes sampling intrinsic cardiac nerve activity at a high sample rate, filtering the sampled signal with a high pass filter, comparing the filtered signal to a predetermined threshold, and initiating a therapeutic action in response to the filtered signal exceeding the predetermined threshold. The intrinsic cardiac nerve activity may be received through an electrode implanted on the heart or from an electrode inserted into the venous structure of the heart.

摘要翻译： 已经开发了一种从患者心脏获得的内在心脏神经信号中检测心律失常的方法。 该方法包括以高采样率对固有的心脏神经活动进行采样，用高通滤波器对采样信号进行滤波，将滤波的信号与预定的阈值进行比较，以及响应于经过滤波的信号超过预定阈值启动治疗动作。 可以通过植入在心脏上的电极或插入到心脏静脉结构中的电极来接收固有的心脏神经活动。

公开(公告)号：US07266410B2

公开(公告)日：2007-09-04

申请号：US11069753

申请日：2005-02-28

申请人： Peng-Sheng Chen

发明人： Peng-Sheng Chen

IPC分类号： A61N1/362 ,  A61B5/0402

CPC分类号： A61B5/04001 ,  A61N1/36585 ,  A61N1/37258 ,  A61N1/3962

摘要： Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.

摘要翻译： 提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性与增加的交感神经放电相关的增加的可能性。 方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。 所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。 可用于与递送有关的药理学试剂包括已知能发挥抗心律失常作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。 其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

公开(公告)号：US20060019954A1

公开(公告)日：2006-01-26

申请号：US10895013

申请日：2004-07-20

申请人： Peng-Sheng Chen

发明人： Peng-Sheng Chen

IPC分类号： A61K31/537

CPC分类号： A61K31/537

摘要： A method is described for reducing the likelihood of the occurrence of a cardiac arrhythmias of the type leading to sudden cardiac death in a mammalian subject. The method comprises administering to the mammalian subject an effective amount of a composition to agonize β3 adrenergic receptors in the mammalian subject. The composition may comprise one or more agents that are known to agonize β3 adrenergic receptors, such as BRL 37344, CPG 12177, CL 316243, SR 58661, pindolol, and cyanopindolol.

摘要翻译： 描述了一种用于降低在哺乳动物受试者中导致心脏猝死的类型的心律失常发生的可能性的方法。 该方法包括向哺乳动物受试者施用有效量的组合物以激动哺乳动物受试者中的β3肾上腺素能受体。 组合物可以包含一种或多种已知可激动β3肾上腺素能受体的试剂，例如BRL 37344，CPG 12177，CL 316243，SR 58661，吲哚洛尔和氰基吲哚洛尔。

公开(公告)号：US20060004414A1

公开(公告)日：2006-01-05

申请号：US11069753

申请日：2005-02-28

申请人： Peng-Sheng Chen

发明人： Peng-Sheng Chen

IPC分类号： A61N1/362 ,  A61B5/0402

CPC分类号： A61B5/04001 ,  A61N1/36585 ,  A61N1/37258 ,  A61N1/3962

摘要： Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.

公开(公告)号：US06487450B1

公开(公告)日：2002-11-26

申请号：US09513059

申请日：2000-02-24

申请人： Peng-Sheng Chen

发明人： Peng-Sheng Chen

IPC分类号： A61M500

CPC分类号： A61N1/36114

摘要： A system and method are described for reducing the likelihood of the occurrence of ventricular arrhythmia in the heart of a patient having a myocardial infarction and an atrioventricular block, particularly a ventricular arrhythmia of the type potentially leading to Sudden Cardiac Death. The likelihood of the occurrence of the ventricular arrhythmia is reduced by stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient. Myocardial hyperinnervation in the sinus node and right ventricle is stimulated by applying electrical stimulation to the right stellate ganglion of the patient or by applying Nerve Growth Factor or other neurotrophic substance to the right stellate ganglion. The system and method may also be advantageously exploited for use with patients having myocardial infarction but no atrioventricular block and for patients have other heart conditions such as Brugada syndrome.

摘要翻译： 描述了一种系统和方法，用于降低患有心肌梗塞和房室传导阻滞的患者的心脏中发生室性心律失常的可能性，特别是可能导致突发性心脏死亡的类型的室性心律失常。 通过刺激患者心脏的窦房结和右心室的心肌超调，降低心室心律失常发生的可能性。 通过对患者的右星状神经节施加电刺激或通过将神经生长因子或其他神经营养物质施用于右星状神经节来刺激窦房结和右心室的心肌超调。 该系统和方法还可以有利地用于患有心肌梗塞但不具有房室传导阻滞的患者，并且患者具有其他心脏状况如Brugada综合征。