公开(公告)号：US5399584A

公开(公告)日：1995-03-21

申请号：US15771

申请日：1993-02-10

申请人： Jeffrey J. Ares ,  Sunil V. Kakodkar ,  Gary R. Kelm ,  Peter D. Murray ,  Jared L. Randall ,  Candice L. Slough

发明人： Jeffrey J. Ares ,  Sunil V. Kakodkar ,  Gary R. Kelm ,  Peter D. Murray ,  Jared L. Randall ,  Candice L. Slough

IPC分类号： A61K31/35 ,  A61K31/38 ,  A61K31/19 ,  A61K31/40 ,  A61K49/00

CPC分类号： A61K31/38 ,  A61K31/35 ,  Y10S514/922 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927

摘要： The subject invention relates to methods for preventing or treating damage to the mucosal lining of the gastrointestinal tract of a human or lower animal by administering a safe and effective amount of a compound having the structure: ##STR1## wherein X and Y are each independently selected from O and S; R.sup.1, R.sup.2 and R.sup.3 are each independently selected from hydrogen, hydroxy, halo, unsubstituted or monosubstituted straight or branched C.sub.1 -C.sub.4 alkanyl, and unsubstituted or substituted straight or branched C.sub.1 -C.sub.4 alkanoxy; and each of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is hydrogen or, if one or more of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, each of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is selected from hydrogen, halo, trifluoromethyl, and unsubstituted straight or branched C.sub.1 -C.sub.4 alkanyl.

摘要翻译： 本发明涉及通过施用安全有效量的具有以下结构的化合物来预防或治疗对人或其以下动物的胃肠道粘膜的损伤的方法：其中X和Y各自独立地选择 从O和S; R 1，R 2和R 3各自独立地选自氢，羟基，卤素，未取代或单取代的直链或支链C 1 -C 4烷基，以及未取代或取代的直链或支链C 1 -C 4烷氧基; R 4，R 5，R 6和R 7各自为氢，或者如果R 1，R 2和R 3中的一个或多个不是氢，则R 4，R 5，R 6和R 7各自选自氢，卤素，三氟甲基和未取代的直链 或支链C 1 -C 4烷基。