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1.发明授权Generating artificial hyperspectral images using correlated analysis of co-registered images 有权使用共同注册图像的相关分析生成人造高光谱图像公开(公告)号：US08699769B2
公开(公告)日：2014-04-15
申请号：US13546182
申请日：2012-07-11
CPC分类号： G06T7/0012 , G06T11/206 , G06T2207/10061 , G06T2207/20016 , G06T2207/20021 , G06T2207/20221
摘要： High-resolution digital images of adjacent slices of a tissue sample are acquired, and tiles are defined in the images. Values associated with image objects detected in each tile are calculated. The tiles in adjacent images are co-registered. A first hyperspectral image is generated using a first image, and a second hyperspectral image is generated using a second image. A first pixel of the first hyperspectral image has a first pixel value corresponding to a local value obtained using image analysis on a tile in the first image. A second pixel of the second hyperspectral image has a second pixel value corresponding to a local value calculated from a tile in the second image. A third hyperspectral image is generated by combining the first and second hyperspectral images. The third hyperspectral image is then displayed on a computer monitor using a false-color encoding generated using the first and second pixel values.
摘要翻译： 获取组织样本的相邻切片的高分辨率数字图像，并且在图像中定义瓦片。 计算与每个图块中检测到的图像对象相关联的值。 相邻图像中的瓦片共同注册。 使用第一图像生成第一高光谱图像，并且使用第二图像生成第二高光谱图像。 第一高光谱图像的第一像素具有对应于在第一图像中的图块上使用图像分析获得的局部值的第一像素值。 第二高光谱图像的第二像素具有对应于从第二图像中的图块计算的局部值的第二像素值。 通过组合第一和第二高光谱图像来生成第三高光谱图像。 然后，使用使用第一和第二像素值生成的伪色编码，在计算机监视器上显示第三高光谱图像。
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公开(公告)号：US09740912B2
公开(公告)日：2017-08-22
申请号：US13330900
申请日：2011-12-20
CPC分类号： G06K9/0014 , G06T7/33 , G06T2207/10056 , G06T2207/30024
摘要： A method for co-registering images of tissue slices stained with different biomarkers displays a first digital image of a first tissue slice on a graphical user interface such that an area of the first image is enclosed by a frame. Then a portion of a second image of a second tissue slice is displayed such that the area of the first image enclosed by the frame is co-registered with the displayed portion of the second image. The displayed portion of the second image has the shape of the frame. The tissue slices are both z slices of a tissue sample taken at corresponding positions in the x and y dimensions. The displayed portion of the second image is shifted in the x and y dimensions to coincide with the area of the first image that is enclosed by the frame as the user shifts the first image under the frame.
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3.发明申请Generating Artificial Hyperspectral Images Using Correlated Analysis of Co-Registered Images 有权使用相关分析共同注册的图像生成人造高光谱图像公开(公告)号：US20130016886A1
公开(公告)日：2013-01-17
申请号：US13546182
申请日：2012-07-11
IPC分类号： G06K9/50
CPC分类号： G06T7/0012 , G06T11/206 , G06T2207/10061 , G06T2207/20016 , G06T2207/20021 , G06T2207/20221
摘要： High-resolution digital images of adjacent slices of a tissue sample are acquired, and tiles are defined in the images. Values associated with image objects detected in each tile are calculated. The tiles in adjacent images are co-registered. A first hyperspectral image is generated using a first image, and a second hyperspectral image is generated using a second image. A first pixel of the first hyperspectral image has a first pixel value corresponding to a local value obtained using image analysis on a tile in the first image. A second pixel of the second hyperspectral image has a second pixel value corresponding to a local value calculated from a tile in the second image. A third hyperspectral image is generated by combining the first and second hyperspectral images. The third hyperspectral image is then displayed on a computer monitor using a false-color encoding generated using the first and second pixel values.
摘要翻译： 获取组织样本的相邻切片的高分辨率数字图像，并且在图像中定义瓦片。 计算与每个图块中检测到的图像对象相关联的值。 相邻图像中的瓦片共同注册。 使用第一图像生成第一高光谱图像，并且使用第二图像生成第二高光谱图像。 第一高光谱图像的第一像素具有对应于在第一图像中的图块上使用图像分析获得的局部值的第一像素值。 第二高光谱图像的第二像素具有对应于从第二图像中的图块计算的局部值的第二像素值。 通过组合第一和第二高光谱图像来生成第三高光谱图像。 然后，使用使用第一和第二像素值生成的伪色编码，在计算机监视器上显示第三高光谱图像。
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4.发明申请公开(公告)号：US20130156279A1
公开(公告)日：2013-06-20
申请号：US13330900
申请日：2011-12-20
CPC分类号： G06K9/0014 , G06T7/33 , G06T2207/10056 , G06T2207/30024
摘要： A method for co-registering images of tissue slices stained with different biomarkers displays a first digital image of a first tissue slice on a graphical user interface such that an area of the first image is enclosed by a frame. Then a portion of a second image of a second tissue slice is displayed such that the area of the first image enclosed by the frame is co-registered with the displayed portion of the second image. The displayed portion of the second image has the shape of the frame. The tissue slices are both z slices of a tissue sample taken at corresponding positions in the x and y dimensions. The displayed portion of the second image is shifted in the x and y dimensions to coincide with the area of the first image that is enclosed by the frame as the user shifts the first image under the frame.
摘要翻译： 用不同生物标志物染色的组织切片的共同对准图像的方法在图形用户界面上显示第一组织切片的第一数字图像，使得第一图像的区域被框包围。 然后显示第二组织切片的第二图像的一部分，使得由帧包围的第一图像的区域与第二图像的显示部分共同对准。 第二图像的显示部分具有该帧的形状。 组织切片是在x和y维度的相应位置处取得的组织样本的z切片。 当用户移动帧下的第一图像时，第二图像的显示部分在x和y维度上移位以与由帧包围的第一图像的区域一致。
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