公开(公告)号：US20110256126A1

公开(公告)日：2011-10-20

申请号：US13039201

申请日：2011-03-02

申请人： David P. Arnott ,  Mercedes Z. Balazs ,  Nico Ghilardi ,  Austin L. Gurney ,  Philip E. Haas ,  Sarah Hymowitz ,  James M. Lee ,  Wenjun Ouyang ,  Melissa A. Starovasnik ,  Yan Wu

发明人： David P. Arnott ,  Mercedes Z. Balazs ,  Nico Ghilardi ,  Austin L. Gurney ,  Philip E. Haas ,  Sarah Hymowitz ,  James M. Lee ,  Wenjun Ouyang ,  Melissa A. Starovasnik ,  Yan Wu

IPC分类号： A61K39/395 ,  A61P7/06 ,  A61P7/02 ,  A61P13/12 ,  A61P25/00 ,  A61P1/00 ,  A61P17/00 ,  A61P17/06 ,  A61P11/06 ,  A61P37/06 ,  A61P19/02 ,  A61P31/14

CPC分类号： C07K16/244 ,  A61K38/2073 ,  A61K2039/505 ,  C07K14/54 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/40 ,  G01N2500/10 ,  G01N2800/24 ,  Y02A50/463

摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及一种新型天然存在的人类细胞因子，其由本文称为白细胞介素17A / F（IL-17A / F）的白细胞介素-17和白细胞介素-17F的异源二聚体组成。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的特异性抗体和用于产生 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。

公开(公告)号：US06827077B1

公开(公告)日：2004-12-07

申请号：US10681294

申请日：2003-10-09

申请人： Philip E. Haas

发明人： Philip E. Haas

IPC分类号： A47J3707

CPC分类号： A47J37/0694 ,  A47J33/00 ,  A47J37/067

摘要： An assembly for cooking on a campfire includes a vertical support that has an upper end and a pointed lower end. A grill support is attached to the vertical support and is selectively positionable between the upper and lower ends. The support is elongated and has a first end and a second end. A fastener selectively fastens the grill support in a fixed vertical position to the vertical support. A grill is attached to and bounded by an upwardly extending peripheral wall. The peripheral wall has an inner surface and an outer surface. The outer surface is attached to the second end of the grill support. A plate has a peripheral edge and a hinge hingedly couples the peripheral edge to the inner surface of peripheral wall. The plate is selectively positionable between a horizontal position extending over the grill and a vertical orientation extending upwardly away from the grill.

摘要翻译： 用于在篝火上烹饪的组件包括具有上端和尖端下端的垂直支撑件。 格栅支撑件附接到垂直支撑件并且可选择性地定位在上端和下端之间。 支撑件是细长的并且具有第一端和第二端。 紧固件选择性地将格栅支架固定在垂直支撑件的垂直位置上。 格栅被一个向上延伸的周壁连接并界定。 周壁具有内表面和外表面。 外表面附接到格栅支架的第二端。 板具有周边边缘，并且铰链铰接地将周缘连接到周壁的内表面。 板可以选择性地定位在在格栅上延伸的水平位置和从格栅向上延伸的垂直取向。