公开(公告)号：US08569494B2

公开(公告)日：2013-10-29

申请号：US12910920

申请日：2010-10-25

申请人： Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Gingsee Lee ,  Garrick Packard ,  Jingjing Zhao ,  Patrick Anthony Jokiel ,  Deborah Mortensen ,  Jennifer Riggs ,  Juan Antonio Gamboa ,  Marie Georges Beauchamps ,  Matthew Michael Kreilein ,  Mohit Atul Kothare ,  Sophie Perrin-Ninkovic ,  Philip James Pye ,  William Wei-Hwa Leong ,  Jan Elsner ,  Anusuya Choudhury

发明人： Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Gingsee Lee ,  Garrick Packard ,  Jingjing Zhao ,  Patrick Anthony Jokiel ,  Deborah Mortensen ,  Jennifer Riggs ,  Juan Antonio Gamboa ,  Marie Georges Beauchamps ,  Matthew Michael Kreilein ,  Mohit Atul Kothare ,  Sophie Perrin-Ninkovic ,  Philip James Pye ,  William Wei-Hwa Leong ,  Jan Elsner ,  Anusuya Choudhury

IPC分类号： C07D471/00

CPC分类号： C07D471/04 ,  C07D241/20 ,  C07D487/04 ,  C07D498/14 ,  C07D519/00

摘要： Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.