公开(公告)号：US07153845B2

公开(公告)日：2006-12-26

申请号：US10421840

申请日：2003-04-24

申请人： Howard L. Levine ,  William J. Bologna ,  Philippe J. Cartier ,  Dominique De Ziegler

发明人： Howard L. Levine ,  William J. Bologna ,  Philippe J. Cartier ,  Dominique De Ziegler

IPC分类号： A61K31/33 ,  A61K31/553 ,  A61K31/554

CPC分类号： A61K31/568 ,  A61K9/0034 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059

摘要： A bioadhesive controlled, extended release progressive hydration composition wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process, as necessary or desired, and more importantly may be protected from moisture and the immediate septic environment until well after the patient has applied the composition, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the composition is available for absorption (bioavailable).

摘要翻译： 生物粘附控制的延长释放的进行性水合组合物，其中活性成分可以被保护免受水或周围环境的影响，从而保护其免受代谢或由水分，酶或pH影响引起的其它降解，并使其仅在受控的 率。 活性成分可根据需要或需要在制造过程中得到保护，并且更重要的是可以保护免受潮湿和直接的败血症环境，直到患者施用组合物，然后仅以缓慢和受控的速率 。 正是通过这种进行性水合过程，活性成分在给药后保持多个小时。 还通过进行水合的过程，控制和持续释放是实现的，因为只有作为组合物的水合（水）部分的活性成分的那部分可用于吸收（生物可利用的）。