公开(公告)号：US20240101555A1

公开(公告)日：2024-03-28

申请号：US18256463

申请日：2021-12-14

申请人： Kira A. Armacost ,  Maria Irina Chiriac ,  Danielle M. Hurzy ,  Jeffery C. Kern ,  Jian Liu ,  Peter J. Manley ,  Phillippe Nantermet ,  Michael T. Rudd ,  Vanessa L. Rada ,  Craig A. Stump ,  Merck Sharp & Dohme LLC

发明人： Kira A. Armacost ,  Maria Irina Chiriac ,  Danielle M. Hurzy ,  Jeffrey C. Kern ,  Jian Liu ,  Peter J. Manley ,  Philippe Nantermet ,  Vanessa L. Rada ,  Michael T. Rudd ,  Craig A. Stump

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： The present invention is directed to urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.