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公开(公告)号:US09464021B2
公开(公告)日:2016-10-11
申请号:US14530250
申请日:2014-10-31
申请人: Dilip S. Mehta , Priya Mohan , Mayank Shastri , Ted Reid
发明人: Dilip S. Mehta , Priya Mohan , Mayank Shastri , Ted Reid
IPC分类号: C07C69/76 , C07C46/00 , C07C69/734 , C07C41/18 , C07D339/08 , C07C45/56 , C07C46/02 , C07C69/618
CPC分类号: C07C46/00 , C07C41/18 , C07C45/567 , C07C46/02 , C07C69/618 , C07C69/734 , C07D339/08 , C07C49/255 , C07C43/215 , C07C50/14
摘要: The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)” to overcome isomerization generated due to delocalization of allyliccarbanion on the π-electron cloud of an allylic systems by the conventional synthesis.
摘要翻译: 该描述提供了聚异戊二烯基化醌衍生物如维生素K1,K2和泛醌的区域和立体特异性合成的方法,利用二硫缩醛,特别是1,3-二噻吩介导的Umpolung化学,其沿着新概念“抑制共振离域(IRD)”工作) 以克服由于通过常规合成在烯丙基系统的π电子云上的烯丙基碳阴离子离域产生的异构化。
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公开(公告)号:US20150126763A1
公开(公告)日:2015-05-07
申请号:US14530250
申请日:2014-10-31
申请人: Dilip S. Mehta , Priya Mohan , Mayank Shastri , Ted Reid
发明人: Dilip S. Mehta , Priya Mohan , Mayank Shastri , Ted Reid
IPC分类号: C07C46/00 , C07C69/618
CPC分类号: C07C46/00 , C07C41/18 , C07C45/567 , C07C46/02 , C07C69/618 , C07C69/734 , C07D339/08 , C07C49/255 , C07C43/215 , C07C50/14
摘要: The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)” to overcome isomerization generated due to delocalization of allyliccarbanion on the π-electron cloud of an allylic systems by the conventional synthesis.
摘要翻译: 该描述提供了聚异戊二烯基化醌衍生物如维生素K1,K2和泛醌的区域和立体特异性合成的方法,利用二硫缩醛,特别是1,3-二噻吩介导的Umpolung化学,其沿着新概念“抑制共振离域(IRD)”工作) 克服由于通过常规合成在烯丙基系统的电子云上的烯丙基碳阴离子的离域产生的异构化。
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