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1.发明公开公开(公告)号：US20240228728A1
公开(公告)日：2024-07-11
申请号：US18408278
申请日：2024-01-09
申请人： Protein Evolution Inc. , PARIS SCIENCES ET LETTRES , Centre National de la Recherche Scientifique , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE
发明人： Ludwik Leibler , François Tournilhac , Clément Freymond , Hernan Garate , Louise Bréloy , Andrew Griffiths , Yannick Rondelez , Brian Mansaku , Jack Pallis , Benjamin Gibbs
CPC分类号： C08J11/105 , C08J11/26 , C12N9/18 , C12Y301/01074 , C08J2367/02
摘要： Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some cases, the methods further comprise a thermal annealing step following the step of reacting the polymeric material comprising the crystallizable polymer or copolymer with the reactive agent and prior to the step of exposing the pretreated polymeric material to the polymer-degrading enzyme. During the thermal annealing step, further chain reactions (e.g., chain scission, extension, branching, and/or cross-linking) may occur.
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2.发明申请公开(公告)号：US20210174903A1
公开(公告)日：2021-06-10
申请号：US17118421
申请日：2020-12-10
发明人： Jonathan M. Rothberg , Brian Reed , Eric Kauderer-Abrams , Zhizhuo Zhang , Mohammad Moghadamfalahi
摘要： The present disclosure provides, in some aspects, methods for enhanced protein structure prediction using protein homology discovery and constrained distograms.
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公开(公告)号：US20240352064A1
公开(公告)日：2024-10-24
申请号：US18610932
申请日：2024-03-20
发明人： Brian Mansaku , Benjamin Gibbs
摘要： Certain aspects of this disclosure are generally related to methods for separating a plurality of particles from a fluid. In some embodiments, the fluid comprises one or more polypeptides and a plurality of particles. In some embodiments, the method comprises at least partially denaturing a polypeptide in the fluid to form a denatured polypeptide. In some embodiments, the method comprises separating a mixture of the denatured polypeptide and at least 10% of a plurality of particles from the fluid. Without wishing to be bound by any particular theory, the denaturation of the polypeptide in the fluid may allow for some of the plurality of particles to associate with the denatured polypeptide, and/or agglomerate with the denatured polypeptide. The mixture comprising the denatured polypeptide and the plurality of particles may settle (e.g., precipitate) in the fluid and may therefore be separated from the fluid.
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公开(公告)号：US20220139496A1
公开(公告)日：2022-05-05
申请号：US17529936
申请日：2021-11-18
摘要： The present disclosure provides methods, compositions, kits, and systems for identifying recombinases and cognate site-specific recombinase recognition sites as well as method for using the identified recombinase/recognition site pairs.
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5.发明公开公开(公告)号：US20240228727A1
公开(公告)日：2024-07-11
申请号：US18408255
申请日：2024-01-09
申请人： Protein Evolution Inc. , PARIS SCIENCES ET LETTRES , Centre National de la Recherche Scientifique , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE
发明人： Ludwik Leibler , François Tournilhac , Clément Freymond , Hernan Garate , Louise Bréloy , Andrew Griffiths , Yannick Rondelez , Brian Mansaku , Jack Pallis , Benjamin Gibbs
IPC分类号： C08J11/10
CPC分类号： C08J11/105
摘要： Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some cases, the methods further comprise a thermal annealing step following the step of reacting the polymeric material comprising the crystallizable polymer or copolymer with the reactive agent and prior to the step of exposing the pretreated polymeric material to the polymer-degrading enzyme. During the thermal annealing step, further chain reactions (e.g., chain scission, extension, branching, and/or cross-linking) may occur.
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6.发明公开公开(公告)号：US20240286178A1
公开(公告)日：2024-08-29
申请号：US18408268
申请日：2024-01-09
申请人： Protein Evolution Inc. , PARIS SCIENCES ET LETTRES , Centre National de la Recherche Scientifique , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE
发明人： Ludwik Leibler , François Tournilhac , Clément Freymond , Hernan Garate , Louise Bréloy , Andrew Griffiths , Yannick Rondelez , Brian Mansaku , Jack Pallis , Benjamin Gibbs
CPC分类号： B09B3/60 , C12N9/18 , C12Y301/01074
摘要： Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some cases, the methods further comprise a thermal annealing step following the step of reacting the polymeric material comprising the crystallizable polymer or copolymer with the reactive agent and prior to the step of exposing the pretreated polymeric material to the polymer-degrading enzyme. During the thermal annealing step, further chain reactions (e.g., chain scission, extension, branching, and/or cross-linking) may occur.
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