公开(公告)号：US06713639B1

公开(公告)日：2004-03-30

申请号：US10281615

申请日：2002-10-28

申请人： Mukund Keshao Gurjar ,  Pradeep Kumar ,  Anis Naim Deshmukh ,  Rajesh Kumar Upadhyay ,  Puspesh Kumar Upadhyay

发明人： Mukund Keshao Gurjar ,  Pradeep Kumar ,  Anis Naim Deshmukh ,  Rajesh Kumar Upadhyay ,  Puspesh Kumar Upadhyay

IPC分类号： C07D30720

CPC分类号： C07D307/33

摘要： The present invention relates to a process for the in situ preparation of optically pure (S)-3,4-dihydroxybutyric acid derivatives represented by the Formula [2] and more particularly, to a process which enables preparing optically pure (S)-3-hydroxy-&ggr;-butyrolactone represented by Formula [1] by oxidation of &agr;- or &bgr;-(1,4) linked disaccharide or oligosaccharide with an oxidant under basic condition to give acid and cyclization sequentially under acidic condition to give (S)-3-hydroxy-&ggr;-butyrolactone.

摘要翻译： 本发明涉及一种原位制备由式[2]表示的光学纯的（S）-3,4-二羟基丁酸衍生物的方法，更具体地说，涉及能够制备光学纯的（S）-3 通过在碱性条件下用氧化剂氧化α-或β-（1,4）连接的二糖或寡糖，由式[1]表示的 - 羟基-γ-丁内酯在酸性条件下依次酸化和环化，得到（S） - 3-羟基-γ-丁内酯。