公开(公告)号：US20210040074A1

公开(公告)日：2021-02-11

申请号：US16977897

申请日：2019-03-06

Applicant: David R. Sibley ,  Kathryn D. Luderman ,  Jennie L. Conroy ,  R. Benjamin Free ,  Prashi Jain ,  Noel T. Southall ,  Marc Ferrer ,  Jeffrey Aubé ,  Kevin Frankowski ,  The United States of America,as represented by the Secretary,Department of Health and Human Service ,  University of Kansas ,  The University of North Carolina at Chapel Hill

Inventor： David R. Sibley ,  Kathryn D. Luderman ,  Jennie L. Conroy ,  R. Benjamin Free ,  Prashi Jain ,  Noel T. Southall ,  Marc Ferrer ,  Jeffrey Aubé ,  Kevin Frankowski

IPC: C07D409/12 ,  C07D471/04

Abstract: Disclosed are compounds of formulas (I) and (III) for treating or preventing a disease or disorder responsive to activation of a D1 dopamine receptor agonist in a mammal in need thereof, wherein m, n, R1-R6, and R11-R13 are as defined herein. Examples of such disease or disorder include Alzheimer's Disease, schizophrenia, Parkinson's disease, a dyskinesia, and Huntington's disease.