公开(公告)号：US20240335509A1

公开(公告)日：2024-10-10

申请号：US18712842

申请日：2022-11-25

申请人： RED ROCK REGENERATION INC.

发明人： Sean A.F. Peel ,  Sowmya Shivanna

IPC分类号： A61K38/18 ,  A61K35/32 ,  A61P19/08 ,  C07K14/51 ,  C12N5/077

CPC分类号： A61K38/18 ,  A61K35/32 ,  A61P19/08 ,  C07K14/51 ,  C12N5/0654 ,  C12N2500/14 ,  C12N2500/46

摘要： A process is provided for treating demineralized bone (DB) comprising incubating the DB with a solution of a chaotropic agent at a temperature in the range of about 12° C. to about 30° C. to increase the release of a bone growth factor followed by selectively removing the chaotropic agent while retaining the released growth factor and the DB. A product prepared by the process is also provided as is the use of said product to promote bone formation or bone fusion in a subject in need thereof.