公开(公告)号：US20080318289A1

公开(公告)日：2008-12-25

申请号：US12089279

申请日：2006-05-10

Applicant: Parveen Kumar ,  Hitesh Kumar Malviya ,  Raj Kumar Maurya ,  Aniruddha Shukla

Inventor： Parveen Kumar ,  Hitesh Kumar Malviya ,  Raj Kumar Maurya ,  Aniruddha Shukla

IPC: C12P17/16

CPC classification number: C07D498/18 ,  C12P17/188

Abstract: The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism capable of producing tacrolimus or a salt or derivative thereof under submerged aerobic conditions with fed-batch processing at a high aeration rate.

Abstract translation: 本发明涉及通过在高曝气速率下进行补料分批处理，在浸没需氧条件下培养能够产生他克莫司或其盐或衍生物的微生物来制备他克莫司或其盐或衍生物的改进的发酵方法。